Regulation of thermogenesis by the central melanocortin system

Wei Fan, Adriana Voss-Andreae, Wei Hua Cao, Shaun F. Morrison

Research output: Contribution to journalReview article

52 Scopus citations

Abstract

Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.

Original languageEnglish (US)
Pages (from-to)1800-1813
Number of pages14
JournalPeptides
Volume26
Issue number10
DOIs
StatePublished - Oct 1 2005

Keywords

  • AGRP
  • BAT
  • Central circuits
  • Diet-induced thermogenesis
  • Melanocortin
  • Obesity
  • POMC
  • Pathogenic stimuli
  • Sympathetic nervous system
  • Thermogenesis
  • Thyroid
  • UCP

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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