Regulation of thermogenesis by the central melanocortin system

Wei Fan, Adriana Voss-Andreae, Wei Hua Cao, Shaun Morrison

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Adaptive thermogenesis represents one of the important homeostatic mechanisms by which the body maintains appropriate levels of stored energy and its core temperature. Dysregulation of adaptive thermogenesis promotes obesity. The central melanocortin system, in particular the melanocortin 4 receptor (MC4R) signaling pathway, influences the regulation of every aspect of energy balance, including thermogenesis, and plays a critical role in energy homeostasis in both rodent and man. This review will outline our current understanding of adaptive thermogenesis, focusing on the role of the central melanocortin pathway in the regulation of thermogenesis.

Original languageEnglish (US)
Pages (from-to)1800-1813
Number of pages14
JournalPeptides
Volume26
Issue number10
DOIs
StatePublished - Oct 2005

Fingerprint

Melanocortins
Thermogenesis
Receptor, Melanocortin, Type 4
Energy balance
Rodentia
Homeostasis
Temperature
Obesity

Keywords

  • AGRP
  • BAT
  • Central circuits
  • Diet-induced thermogenesis
  • Melanocortin
  • Obesity
  • Pathogenic stimuli
  • POMC
  • Sympathetic nervous system
  • Thermogenesis
  • Thyroid
  • UCP

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Regulation of thermogenesis by the central melanocortin system. / Fan, Wei; Voss-Andreae, Adriana; Cao, Wei Hua; Morrison, Shaun.

In: Peptides, Vol. 26, No. 10, 10.2005, p. 1800-1813.

Research output: Contribution to journalArticle

Fan, Wei ; Voss-Andreae, Adriana ; Cao, Wei Hua ; Morrison, Shaun. / Regulation of thermogenesis by the central melanocortin system. In: Peptides. 2005 ; Vol. 26, No. 10. pp. 1800-1813.
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