TY - JOUR
T1 - Regulation of T-cell activation by the cytoskeleton
AU - Billadeau, Daniel D.
AU - Nolz, Jeffrey C.
AU - Gomez, Timothy S.
N1 - Funding Information:
The authors apologize to many colleagues whose exciting and important work was not quoted here owing to space constraints. We would like to thank J. Burkhardt, Y. Shimizu and P. Leibson for helpful discussions and critical review of the manuscript. This work was supported by the Mayo Foundation and grants from the US National Institutes of Health.
PY - 2007/2
Y1 - 2007/2
N2 - To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
AB - To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.
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U2 - 10.1038/nri2021
DO - 10.1038/nri2021
M3 - Review article
C2 - 17259969
AN - SCOPUS:33846626054
SN - 1474-1733
VL - 7
SP - 131
EP - 143
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 2
ER -