Regulation of T-cell activation by the cytoskeleton

Daniel D. Billadeau, Jeffrey Nolz, Timothy S. Gomez

Research output: Contribution to journalArticle

230 Citations (Scopus)

Abstract

To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.

Original languageEnglish (US)
Pages (from-to)131-143
Number of pages13
JournalNature Reviews Immunology
Volume7
Issue number2
DOIs
StatePublished - Feb 2007
Externally publishedYes

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Cytoskeleton
T-Lymphocytes
Immunological Synapses
Antigen-Presenting Cells
Integrins
Microtubules
Actins

ASJC Scopus subject areas

  • Immunology

Cite this

Regulation of T-cell activation by the cytoskeleton. / Billadeau, Daniel D.; Nolz, Jeffrey; Gomez, Timothy S.

In: Nature Reviews Immunology, Vol. 7, No. 2, 02.2007, p. 131-143.

Research output: Contribution to journalArticle

Billadeau, Daniel D. ; Nolz, Jeffrey ; Gomez, Timothy S. / Regulation of T-cell activation by the cytoskeleton. In: Nature Reviews Immunology. 2007 ; Vol. 7, No. 2. pp. 131-143.
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