Regulation of somatic growth by the p160 coactivator p/CIP

Zhiyong Wang, David W. Rose, Ola Hermanson, Forrest Liu, Thomas Herman, Wei Wu, Daniel Szeto, Anatoli Gleiberman, Anna Krones, Katherine Pratt, Ron Rosenfeld, Christopher K. Glass, Michael G. Rosenfeld

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167 Scopus citations

Abstract

A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. In this manuscript, we report that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity. Our data suggest that a short stature pheno-type of p/CIP gene-deleted mice reflect both altered regulation of insulin-like growth factor-1 (IGF-1) gene expression in specific tissues and a cell-autonomous defect of response to IGF-1, including ineffective transcriptional activities by several classes of regulated transcription factors under specific conditions. The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals.

Original languageEnglish (US)
Pages (from-to)13549-13554
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number25
DOIs
StatePublished - Dec 5 2000

ASJC Scopus subject areas

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    Wang, Z., Rose, D. W., Hermanson, O., Liu, F., Herman, T., Wu, W., Szeto, D., Gleiberman, A., Krones, A., Pratt, K., Rosenfeld, R., Glass, C. K., & Rosenfeld, M. G. (2000). Regulation of somatic growth by the p160 coactivator p/CIP. Proceedings of the National Academy of Sciences of the United States of America, 97(25), 13549-13554. https://doi.org/10.1073/pnas.260463097