TY - JOUR
T1 - Regulation of somatic growth by the p160 coactivator p/CIP
AU - Wang, Zhiyong
AU - Rose, David W.
AU - Hermanson, Ola
AU - Liu, Forrest
AU - Herman, Thomas
AU - Wu, Wei
AU - Szeto, Daniel
AU - Gleiberman, Anatoli
AU - Krones, Anna
AU - Pratt, Katherine
AU - Rosenfeld, Ron
AU - Glass, Christopher K.
AU - Rosenfeld, Michael G.
PY - 2000/12/5
Y1 - 2000/12/5
N2 - A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. In this manuscript, we report that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity. Our data suggest that a short stature pheno-type of p/CIP gene-deleted mice reflect both altered regulation of insulin-like growth factor-1 (IGF-1) gene expression in specific tissues and a cell-autonomous defect of response to IGF-1, including ineffective transcriptional activities by several classes of regulated transcription factors under specific conditions. The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals.
AB - A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. In this manuscript, we report that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity. Our data suggest that a short stature pheno-type of p/CIP gene-deleted mice reflect both altered regulation of insulin-like growth factor-1 (IGF-1) gene expression in specific tissues and a cell-autonomous defect of response to IGF-1, including ineffective transcriptional activities by several classes of regulated transcription factors under specific conditions. The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals.
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U2 - 10.1073/pnas.260463097
DO - 10.1073/pnas.260463097
M3 - Article
C2 - 11087842
AN - SCOPUS:12944270584
SN - 0027-8424
VL - 97
SP - 13549
EP - 13554
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 25
ER -