Regulation of Respiratory Genes by ResD-ResE Signal Transduction System in Bacillus subtilis

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Scopus citations

Abstract

Successful respiration in Bacillus subtilis using oxygen or nitrate as the terminal electron acceptor requires the ResD-ResE signal transduction system. Although transcription of ResDE-controlled genes is induced at the stationary phase of aerobic growth, it is induced to a higher extent upon oxygen limitation. Furthermore, maximal transcriptional activation requires not only oxygen limitation, but also nitric oxide (NO). Oxygen limitation likely results in conversion of the ResE sensor kinase activity from a phosphatase-dominant to a kinase-dominant mode. In addition, low oxygen levels promote the production and maintenance of NO during nitrate respiration, which leads to elimination of the repression exerted by the NO-sensitive transcriptional regulator NsrR. ResD, after undergoing ResE-mediated phosphorylation, interacts with the C-terminal domain of the α subunit of RNA polymerase to activate transcription initiation at ResDE-controlled promoters.

Original languageEnglish (US)
Title of host publicationTwo Component Signaling Systems, Part A
PublisherAcademic Press Inc.
Pages448-464
Number of pages17
DOIs
StatePublished - Jan 1 2007

Publication series

NameMethods in Enzymology
Volume422
ISSN (Print)0076-6879

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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    Geng, H., Zuber, P., & Nakano, M. M. (2007). Regulation of Respiratory Genes by ResD-ResE Signal Transduction System in Bacillus subtilis. In Two Component Signaling Systems, Part A (pp. 448-464). (Methods in Enzymology; Vol. 422). Academic Press Inc.. https://doi.org/10.1016/S0076-6879(06)22023-8