@inbook{2b327f8d9e91410281ab77b7069952d3,
title = "Regulation of Respiratory Genes by ResD-ResE Signal Transduction System in Bacillus subtilis",
abstract = "Successful respiration in Bacillus subtilis using oxygen or nitrate as the terminal electron acceptor requires the ResD-ResE signal transduction system. Although transcription of ResDE-controlled genes is induced at the stationary phase of aerobic growth, it is induced to a higher extent upon oxygen limitation. Furthermore, maximal transcriptional activation requires not only oxygen limitation, but also nitric oxide (NO). Oxygen limitation likely results in conversion of the ResE sensor kinase activity from a phosphatase-dominant to a kinase-dominant mode. In addition, low oxygen levels promote the production and maintenance of NO during nitrate respiration, which leads to elimination of the repression exerted by the NO-sensitive transcriptional regulator NsrR. ResD, after undergoing ResE-mediated phosphorylation, interacts with the C-terminal domain of the α subunit of RNA polymerase to activate transcription initiation at ResDE-controlled promoters.",
author = "Hao Geng and Peter Zuber and Nakano, {Michiko M.}",
note = "Funding Information: Research in our laboratory was supported by Grant MCB0110513 (to M.M.N.) from the National Science Foundation and Grant GM45898 (to P.Z.) from National Institutes of Health. We are deeply indebted to Shunji Nakano for construction of the α‐CTD library and expression system of the subunits of RNAP. We also thank past and current members in our laboratory for support and enthusiasm.",
year = "2007",
doi = "10.1016/S0076-6879(06)22023-8",
language = "English (US)",
series = "Methods in Enzymology",
publisher = "Academic Press Inc.",
pages = "448--464",
booktitle = "Two Component Signaling Systems, Part A",
}