Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases

Juliette Hadchouel, David Ellison, Gerardo Gamba

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The discovery of four genes responsible for pseudohypoaldosteronism type II, or familial hyperkalemic hypertension, which features arterial hypertension with hyperkalemia and metabolic acidosis, unmasked a complex multiprotein system that regulates electrolyte transport in the distal nephron. Two of these genes encode the serine-threonine kinases WNK1 and WNK4. The other two genes kelch-like 3 (KLHL3) and cullin 3 (CUL3) form a RING-type E3-ubiquitin ligase complex that modulates WNK1 and WNK4 abundance. WNKs regulate the activity of the Na+:Cl- cotransporter (NCC), the epithelial sodium channel (ENaC), the renal outer medullary potassium channel (ROMK), and other transport pathways. Interestingly, the modulation of NCC occurs via the phosphorylation by WNKs of other serine-threonine kinases known as SPAK-OSR1. In contrast, the process of regulating the channels is independent of SPAK-OSR1. We present a review of the remarkable advances in this area in the past 10 years.

Original languageEnglish (US)
Pages (from-to)367-389
Number of pages23
JournalAnnual Review of Physiology
Volume78
DOIs
StatePublished - Feb 10 2016

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Member 3 Solute Carrier Family 12
Protein-Serine-Threonine Kinases
Electrolytes
Phosphotransferases
Pseudohypoaldosteronism
Cullin Proteins
Hypertension
Epithelial Sodium Channels
Kidney
Multiprotein Complexes
Hyperkalemia
Ubiquitin-Protein Ligases
Potassium Channels
Nephrons
Genetic Association Studies
Acidosis
Genes
Phosphorylation

Keywords

  • Diuretics
  • ENaC
  • Hypertension
  • NCC
  • ROMK
  • Salt transport
  • SLC12

ASJC Scopus subject areas

  • Physiology

Cite this

Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases. / Hadchouel, Juliette; Ellison, David; Gamba, Gerardo.

In: Annual Review of Physiology, Vol. 78, 10.02.2016, p. 367-389.

Research output: Contribution to journalArticle

Hadchouel, Juliette ; Ellison, David ; Gamba, Gerardo. / Regulation of Renal Electrolyte Transport by WNK and SPAK-OSR1 Kinases. In: Annual Review of Physiology. 2016 ; Vol. 78. pp. 367-389.
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