Regulation of puberty

Sergio Ojeda, Vincent Prevot, Sabine Heger

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Evidence is presented indicating that the initiation of mammalian puberty requires an array of transsynaptic and glial-neuronal interactions, brought about by neurons using excitatory and inhibitory amino acids as transmitters and astroglial cells producing cell-cell signaling molecules able to regulate neuronal function. Although a glutamate-to-GABA hierarchical arrangement appears prominent in the brain, it is still unclear which of these two neurotransmitter systems is primarily responsible for initiating the transsynaptic cascade of events that unleashes the pubertal increase in LHRH release. In contrast, there is now considerable evidence demonstrating that members of the TGF-β and EGF families of trophic factors are key components of the gila-to-neuron communication pathways used by glial cells to facilitate LHRH release. Progress has also been made toward the identification of genes belonging to the hierarchy of upstream molecules that presumably control the initiation of puberty.

    Original languageEnglish (US)
    Pages (from-to)154-160
    Number of pages7
    JournalCurrent Opinion in Endocrinology and Diabetes
    Volume8
    Issue number3
    DOIs
    StatePublished - 2001

    Fingerprint

    Puberty
    Gonadotropin-Releasing Hormone
    Neuroglia
    Neurons
    Excitatory Amino Acids
    Epidermal Growth Factor
    gamma-Aminobutyric Acid
    Neurotransmitter Agents
    Glutamic Acid
    Brain
    Genes

    ASJC Scopus subject areas

    • Endocrinology
    • Endocrinology, Diabetes and Metabolism
    • Internal Medicine

    Cite this

    Regulation of puberty. / Ojeda, Sergio; Prevot, Vincent; Heger, Sabine.

    In: Current Opinion in Endocrinology and Diabetes, Vol. 8, No. 3, 2001, p. 154-160.

    Research output: Contribution to journalArticle

    Ojeda, Sergio ; Prevot, Vincent ; Heger, Sabine. / Regulation of puberty. In: Current Opinion in Endocrinology and Diabetes. 2001 ; Vol. 8, No. 3. pp. 154-160.
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