Regulation of mRNA expression in breast cancer - a cis-tematic trans-action

Roel G W Verhaak, Gordon Mills

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Abstract

Large research consortia such as the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), The Cancer Genome Atlas and International Cancer Genomics Consortium are systematically interrogating large sets of tumor samples through integrated analysis of genome-wide DNA copy number and promoter methylation, transcriptome-wide RNA expression, protein expression and exome-wide sequencing. A recent METABRIC study explored the effects of cis-acting and trans-acting factors of gene expression regulation in breast cancer. By making their data sets publicly available, these large consortia are inviting new types of analysis that have the potential to drive breast cancer research into previously unexplored avenues.

Original languageEnglish (US)
Article number322
JournalBreast Cancer Research
Volume14
Issue number5
DOIs
StatePublished - Oct 29 2012
Externally publishedYes

Fingerprint

Breast Neoplasms
Messenger RNA
Genome
Exome
Neoplasms
Trans-Activators
Atlases
Gene Expression Regulation
Genomics
Transcriptome
Research
Methylation
RNA
DNA
Proteins
Datasets

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Regulation of mRNA expression in breast cancer - a cis-tematic trans-action. / Verhaak, Roel G W; Mills, Gordon.

In: Breast Cancer Research, Vol. 14, No. 5, 322, 29.10.2012.

Research output: Contribution to journalComment/debate

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