Regulation of mRNA expression in breast cancer - a cis-tematic trans-action

Roel G.W. Verhaak, Gordon B. Mills

    Research output: Contribution to journalComment/debate

    1 Scopus citations

    Abstract

    Large research consortia such as the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), The Cancer Genome Atlas and International Cancer Genomics Consortium are systematically interrogating large sets of tumor samples through integrated analysis of genome-wide DNA copy number and promoter methylation, transcriptome-wide RNA expression, protein expression and exome-wide sequencing. A recent METABRIC study explored the effects of cis-acting and trans-acting factors of gene expression regulation in breast cancer. By making their data sets publicly available, these large consortia are inviting new types of analysis that have the potential to drive breast cancer research into previously unexplored avenues.

    Original languageEnglish (US)
    Article number322
    JournalBreast Cancer Research
    Volume14
    Issue number5
    DOIs
    StatePublished - Oct 29 2012

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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