Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae

P. A. Tower, D. B. Alexander, L. L. Johnson, Michael Riscoe

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

5-Methylthioribose (MTR) kinase catalyses a key step in the recycling of methionine from 5'-methylthioadenosine, a co-product of polyamine biosynthesis, in Klebsiella pneumoniae. In defined medium lacking methionine, K. pneumoniae exhibits abundant MTR kinase activity. When the bacterium is transferred to a medium containing 10 mM-methionine, the specific activity of MTR kinase decreases in a fashion consistent with repression of new enzyme synthesis and dilution of existing enzyme by cell division. The specific activity of methionine synthase decreases to a similar degree under the same conditions. In Escherichia coli and Salmonella typhimurium, the gene for methionine synthase is co-ordinately controlled as part of the methionine regulon. Taken together, our results indicate that a methionine regulon may function in K. pneumoniae and that expression of MTR kinase may be under its control.

Original languageEnglish (US)
Pages (from-to)1027-1031
Number of pages5
JournalJournal of General Microbiology
Volume139
Issue number5
StatePublished - 1993
Externally publishedYes

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Klebsiella pneumoniae
Methionine
Phosphotransferases
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Regulon
Enzyme Repression
Polyamines
Recycling
Salmonella typhimurium
Cell Division
Escherichia coli
Bacteria
5-methylthioribose kinase
Enzymes
Genes

ASJC Scopus subject areas

  • Microbiology

Cite this

Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae. / Tower, P. A.; Alexander, D. B.; Johnson, L. L.; Riscoe, Michael.

In: Journal of General Microbiology, Vol. 139, No. 5, 1993, p. 1027-1031.

Research output: Contribution to journalArticle

Tower, PA, Alexander, DB, Johnson, LL & Riscoe, M 1993, 'Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae', Journal of General Microbiology, vol. 139, no. 5, pp. 1027-1031.
Tower, P. A. ; Alexander, D. B. ; Johnson, L. L. ; Riscoe, Michael. / Regulation of methylthioribose kinase by methionine in Klebsiella pneumoniae. In: Journal of General Microbiology. 1993 ; Vol. 139, No. 5. pp. 1027-1031.
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