Regulation of latency and reactivation by human cytomegalovirus miRNAs

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1 Scopus citations

Abstract

Human cytomegalovirus (HCMV) encodes 22 mature microRNAs (miRNAs), which regulate a myriad of cellular processes, including vesicular trafficking, cell cycle progression, apoptosis, and immune evasion, as well as viral gene expression. Recent evidence points to a critical role for HCMV miRNAs in mediating latency in CD34+ hematopoietic progenitor cells through modulation of cellular signaling pathways, including attenuation of TGF and EGFR signaling. Moreover, HCMV miRNAs can act in concert with, or in opposition to, viral proteins in regulating host cell functions. Here, we comprehensively review the studies of HCMV miRNAs in the context of latency and highlight the novel processes that are manipulated by the virus using these small non-coding RNAs.

Original languageEnglish (US)
Article number200
Pages (from-to)1-15
Number of pages15
JournalPathogens
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Cytomegalovirus
  • Latency
  • MiRNA
  • Signaling

ASJC Scopus subject areas

  • Immunology and Allergy
  • Molecular Biology
  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

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