Regulation of invadopodia by the tumor microenvironment

Christine M. Gould, Sara Courtneidge

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The tumor microenvironment consists of stromal cells, extracellular matrix (ECM), and signaling molecules that communicate with cancer cells. As tumors grow and develop, the tumor microenvironment changes. In addition, the tumor microenvironment is not only influenced by signals from tumor cells, but also stromal components contribute to tumor progression and metastasis by affecting cancer cell function. One of the mechanisms that cancer cells use to invade and metastasize is mediated by actin-rich, proteolytic structures called invadopodia. Here, we discuss how signals from the tumor environment, including growth factors, hypoxia, pH, metabolism, and stromal cell interactions, affect the formation and function of invadopodia to regulate cancer cell invasion and metastasis. Understanding how the tumor microenvironment affects invadopodia biology could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.

Original languageEnglish (US)
Pages (from-to)226-235
Number of pages10
JournalCell Adhesion and Migration
Volume8
Issue number3
DOIs
StatePublished - May 1 2014
Externally publishedYes

Fingerprint

Tumor Microenvironment
Neoplasms
Stromal Cells
Neoplasm Metastasis
Podosomes
Cell Communication
Extracellular Matrix
Actins
Intercellular Signaling Peptides and Proteins

Keywords

  • Hypoxia
  • Invadopodia
  • Metastasis
  • Podosomes
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

Cite this

Regulation of invadopodia by the tumor microenvironment. / Gould, Christine M.; Courtneidge, Sara.

In: Cell Adhesion and Migration, Vol. 8, No. 3, 01.05.2014, p. 226-235.

Research output: Contribution to journalArticle

@article{ced0f5daaec64a6b9db91aa8c22b2f3b,
title = "Regulation of invadopodia by the tumor microenvironment",
abstract = "The tumor microenvironment consists of stromal cells, extracellular matrix (ECM), and signaling molecules that communicate with cancer cells. As tumors grow and develop, the tumor microenvironment changes. In addition, the tumor microenvironment is not only influenced by signals from tumor cells, but also stromal components contribute to tumor progression and metastasis by affecting cancer cell function. One of the mechanisms that cancer cells use to invade and metastasize is mediated by actin-rich, proteolytic structures called invadopodia. Here, we discuss how signals from the tumor environment, including growth factors, hypoxia, pH, metabolism, and stromal cell interactions, affect the formation and function of invadopodia to regulate cancer cell invasion and metastasis. Understanding how the tumor microenvironment affects invadopodia biology could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.",
keywords = "Hypoxia, Invadopodia, Metastasis, Podosomes, Tumor microenvironment",
author = "Gould, {Christine M.} and Sara Courtneidge",
year = "2014",
month = "5",
day = "1",
doi = "10.4161/cam.28346",
language = "English (US)",
volume = "8",
pages = "226--235",
journal = "Cell Adhesion and Migration",
issn = "1933-6918",
publisher = "Landes Bioscience",
number = "3",

}

TY - JOUR

T1 - Regulation of invadopodia by the tumor microenvironment

AU - Gould, Christine M.

AU - Courtneidge, Sara

PY - 2014/5/1

Y1 - 2014/5/1

N2 - The tumor microenvironment consists of stromal cells, extracellular matrix (ECM), and signaling molecules that communicate with cancer cells. As tumors grow and develop, the tumor microenvironment changes. In addition, the tumor microenvironment is not only influenced by signals from tumor cells, but also stromal components contribute to tumor progression and metastasis by affecting cancer cell function. One of the mechanisms that cancer cells use to invade and metastasize is mediated by actin-rich, proteolytic structures called invadopodia. Here, we discuss how signals from the tumor environment, including growth factors, hypoxia, pH, metabolism, and stromal cell interactions, affect the formation and function of invadopodia to regulate cancer cell invasion and metastasis. Understanding how the tumor microenvironment affects invadopodia biology could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.

AB - The tumor microenvironment consists of stromal cells, extracellular matrix (ECM), and signaling molecules that communicate with cancer cells. As tumors grow and develop, the tumor microenvironment changes. In addition, the tumor microenvironment is not only influenced by signals from tumor cells, but also stromal components contribute to tumor progression and metastasis by affecting cancer cell function. One of the mechanisms that cancer cells use to invade and metastasize is mediated by actin-rich, proteolytic structures called invadopodia. Here, we discuss how signals from the tumor environment, including growth factors, hypoxia, pH, metabolism, and stromal cell interactions, affect the formation and function of invadopodia to regulate cancer cell invasion and metastasis. Understanding how the tumor microenvironment affects invadopodia biology could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.

KW - Hypoxia

KW - Invadopodia

KW - Metastasis

KW - Podosomes

KW - Tumor microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84901433450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901433450&partnerID=8YFLogxK

U2 - 10.4161/cam.28346

DO - 10.4161/cam.28346

M3 - Article

C2 - 24714597

AN - SCOPUS:84901433450

VL - 8

SP - 226

EP - 235

JO - Cell Adhesion and Migration

JF - Cell Adhesion and Migration

SN - 1933-6918

IS - 3

ER -