Regulation of invadopodia by the tumor microenvironment

Christine M. Gould, Sara A. Courtneidge

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

The tumor microenvironment consists of stromal cells, extracellular matrix (ECM), and signaling molecules that communicate with cancer cells. As tumors grow and develop, the tumor microenvironment changes. In addition, the tumor microenvironment is not only influenced by signals from tumor cells, but also stromal components contribute to tumor progression and metastasis by affecting cancer cell function. One of the mechanisms that cancer cells use to invade and metastasize is mediated by actin-rich, proteolytic structures called invadopodia. Here, we discuss how signals from the tumor environment, including growth factors, hypoxia, pH, metabolism, and stromal cell interactions, affect the formation and function of invadopodia to regulate cancer cell invasion and metastasis. Understanding how the tumor microenvironment affects invadopodia biology could aid in the development of effective therapeutics to target cancer cell invasion and metastasis.

Original languageEnglish (US)
Pages (from-to)226-235
Number of pages10
JournalCell Adhesion and Migration
Volume8
Issue number3
DOIs
StatePublished - May 1 2014

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Keywords

  • Hypoxia
  • Invadopodia
  • Metastasis
  • Podosomes
  • Tumor microenvironment

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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