Abstract
Stem cells are essential for maintaining the tissue integrity of all adult tissues. The manipulation of adult stem cells has the potential for cell regeneration and in curing diseases; however, the intestinal stem cell remains enigmatic. Although much work has focused on characterization of the intestinal stem cell within its in vivo niche, the lack of reliable markers complicates its isolation and therefore its in vitro manipulation. Understanding what regulates the intestinal stem cell within its niche will provide valuable insight into how these cells can be manipulated in culture. Comparing the regulation of this niche in the developing and mature intestine is a valuable untapped resource. A small number of signaling pathways are functionally conserved during development. These pathways are beginning to emerge as critical regulators of the stem cell niche. This review focuses on the regulation of the intestinal stem cell niche.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 224-228 |
| Number of pages | 5 |
| Journal | Journal of Investigative Dermatology Symposium Proceedings |
| Volume | 9 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 2004 |
Fingerprint
Keywords
- Intestinal stem cell
- Regulation
- Small intestine
- Wnt signaling
ASJC Scopus subject areas
- Dermatology
Cite this
Regulation of intestinal stem cells. / Wong, Melissa.
In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 9, No. 3, 09.2004, p. 224-228.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of intestinal stem cells
AU - Wong, Melissa
PY - 2004/9
Y1 - 2004/9
N2 - Stem cells are essential for maintaining the tissue integrity of all adult tissues. The manipulation of adult stem cells has the potential for cell regeneration and in curing diseases; however, the intestinal stem cell remains enigmatic. Although much work has focused on characterization of the intestinal stem cell within its in vivo niche, the lack of reliable markers complicates its isolation and therefore its in vitro manipulation. Understanding what regulates the intestinal stem cell within its niche will provide valuable insight into how these cells can be manipulated in culture. Comparing the regulation of this niche in the developing and mature intestine is a valuable untapped resource. A small number of signaling pathways are functionally conserved during development. These pathways are beginning to emerge as critical regulators of the stem cell niche. This review focuses on the regulation of the intestinal stem cell niche.
AB - Stem cells are essential for maintaining the tissue integrity of all adult tissues. The manipulation of adult stem cells has the potential for cell regeneration and in curing diseases; however, the intestinal stem cell remains enigmatic. Although much work has focused on characterization of the intestinal stem cell within its in vivo niche, the lack of reliable markers complicates its isolation and therefore its in vitro manipulation. Understanding what regulates the intestinal stem cell within its niche will provide valuable insight into how these cells can be manipulated in culture. Comparing the regulation of this niche in the developing and mature intestine is a valuable untapped resource. A small number of signaling pathways are functionally conserved during development. These pathways are beginning to emerge as critical regulators of the stem cell niche. This review focuses on the regulation of the intestinal stem cell niche.
KW - Intestinal stem cell
KW - Regulation
KW - Small intestine
KW - Wnt signaling
UR - http://www.scopus.com/inward/record.url?scp=4243156105&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4243156105&partnerID=8YFLogxK
U2 - 10.1111/j.1087-0024.2004.09304.x
DO - 10.1111/j.1087-0024.2004.09304.x
M3 - Article
VL - 9
SP - 224
EP - 228
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
SN - 1087-0024
IS - 3
ER -