Regulation of immune cell signaling by activated protein C

Laura D. Healy, Rachel A. Rigg, John H. Griffin, Owen J.T. McCarty

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Innate immune cells are an essential part of the host defense response, promoting inflammation through release of proinflammatory cytokines or formation of neutrophil extracellular traps. While these processes are important for defense against infectious agents or injury, aberrant activation potentiates pathologic inflammatory disease. Thus, understanding regulatory mechanisms that limit neutrophil extracellular traps formation and cytokine release is of therapeutic interest for targeting pathologic diseases. Activated protein C is an endogenous serine protease with anticoagulant activity as well as anti-inflammatory and cytoprotective functions, the latter of which are mediated through binding cell surface receptors and inducing intracellular signaling. In this review, we discuss certain leukocyte functions, namely neutrophil extracellular traps formation and cytokine release, and the inhibition of these processes by activated protein C.

Original languageEnglish (US)
Pages (from-to)1197-1203
Number of pages7
JournalJournal of Leukocyte Biology
Volume103
Issue number6
DOIs
StatePublished - Jun 2018

Keywords

  • APC
  • EPCR
  • Mac-1
  • PAR1
  • PAR3
  • activated protein C
  • neutrophils
  • sepsis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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