Regulation of hypothalamic luteinizing hormone-releasing hormone levels by testosterone and estradiol in male rhesus monkeys

Charles E. Roselli, John A. Resko

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14 Scopus citations


Castration of rhesus monkeys produces hypersecretion of pituitary luteinizing hormone (LH) and a marked reduction in hypothalamic luteinizing hormone-releasing hormone (LH-RH) content. We performed the present study to determine whether treatment with gonadal steroids would reverse the effect of castration by increasing LH-RH content. We found that, when administered in doses that suppressed serum LH, both testosterone (T) and estradiol (E) significantly increased LH-RH in the infundibular nucleus/median eminence. The LH-RH content of 8 other regions, some known to contain LH-RH neurons, was not significantly affected. Thus, gonadal steroids act within a discrete region of the basal hypothalamus to modify LH-RH content. The finding that both T and E were effective in male monkeys supports the hypothesis that aromatization is involved in the negative feedback mechanism.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalBrain research
Issue number2
StatePublished - Feb 19 1990



  • Castration
  • Estradiol
  • Hypothalamus
  • Luteinizing hormone-releasing hormone
  • Rhesus monkey
  • Testosterone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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