Regulation of gene expression in human cancers by TRIM24

Srikanth Appikonda, Kaushik N. Thakkar, Michelle Craig Barton

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

Tripartite Motif-containing protein 24 (TRIM24) functions as an E3 ligase targeting p53 for ubiquitination, a histone ‘reader’ that interacts with a specific signature of histone post-translational modifications and a co-regulator of nuclear receptor-regulated transcription. Although mouse models of Trim24 depletion suggest that TRIM24 may be a liver-specific tumor suppressor, several studies show that human TRIM24 is an oncogene when aberrantly over expressed. This review focuses on the mechanisms of TRIM24 functions in oncogenesis and metabolic reprogramming, which underlie recent interest in therapeutic targeting of aberrant TRIM24 in human cancers.

Original languageEnglish (US)
Pages (from-to)57-63
Number of pages7
JournalDrug Discovery Today: Technologies
Volume19
DOIs
StatePublished - Mar 1 2016
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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