Regulation of gene expression by polyunsaturated fatty acids

Harini Sampath, James M. Ntambi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Consumption of polyunsaturated fatty acids (PUFAs) has been shown to be beneficial in the prevention of several human diseases, including obesity, diabetes, heart disease, and stroke. It has become clear that linolenic (n-3) and linoleic (n-6) PUFAs can act at the nuclear level to affect expression of genes involved in diverse metabolic pathways. PUFAs act via nuclear receptors such as peroxisome proliferator activated receptor α and liver X receptor α, and through the transcription factor, sterol regulatory element binding protein-1c, to elicit a favorable hypolipidemic phenotype. Further understanding of the molecular effects of PUFAs will be key to devising novel approaches to the treatment and prevention of disease.

Original languageEnglish (US)
Pages (from-to)32-35
Number of pages4
JournalHeart and Metabolism
Issue number32
StatePublished - 2006
Externally publishedYes

Fingerprint

Gene Expression Regulation
Unsaturated Fatty Acids
Sterol Regulatory Element Binding Protein 1
Peroxisome Proliferator-Activated Receptors
Cytoplasmic and Nuclear Receptors
Metabolic Networks and Pathways
Heart Diseases
Transcription Factors
Obesity
Stroke
Phenotype
Gene Expression

Keywords

  • LXRα
  • Polyunsaturated fatty acids
  • PPARα
  • SREBP1c

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Sampath, H., & Ntambi, J. M. (2006). Regulation of gene expression by polyunsaturated fatty acids. Heart and Metabolism, (32), 32-35.

Regulation of gene expression by polyunsaturated fatty acids. / Sampath, Harini; Ntambi, James M.

In: Heart and Metabolism, No. 32, 2006, p. 32-35.

Research output: Contribution to journalArticle

Sampath, H & Ntambi, JM 2006, 'Regulation of gene expression by polyunsaturated fatty acids', Heart and Metabolism, no. 32, pp. 32-35.
Sampath, Harini ; Ntambi, James M. / Regulation of gene expression by polyunsaturated fatty acids. In: Heart and Metabolism. 2006 ; No. 32. pp. 32-35.
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