Regulation of fetal placental blood flow in the lamb

D. F. Anderson, J. J. Faber

    Research output: Contribution to journalArticle

    26 Scopus citations

    Abstract

    Inflatable occluders were placed on the distal aorta of 11 fetal lambs. After 1 wk of control measurements, fetal placental blood flow was reduced to about two-thirds of its control value for an average period of 2 wk. No allowance was made for fetal growth. During the period of flow restriction, fetal growth was 2%/day. Femoral arterial blood pressure was reduced from a control value of 41 to 27 mmHg (P < 0.001). There was an insignificant increase in carotid arterial blood pressure from 48 to 50 mmHg. Placental resistance to flow did not decrease more than could be accounted for by the increase in gestational age in the course of the experiment. It is concluded that fetal placental blood flow is not under feedback control, since neither of the determinants of flow (i.e., driving pressure and resistance) responded to its chronic reduction.

    Original languageEnglish (US)
    Pages (from-to)R567-R574
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume16
    Issue number3
    StatePublished - Jan 1 1984

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

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