Regulation of endogenous conductances in GnRH neurons by estrogens

Oline Ronnekleiv, Martha A. Bosch, Chunguang Zhang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

17β-estradiol (E2) regulates the activity of the gonadotropin- releasing hormone (GnRH) neurons through both presynaptic and postsynaptic mechanisms, and this ovarian steroid hormone is essential for cyclical GnRH neuronal activity and secretion. E2 has significant actions to modulate the mRNA expression of numerous ion channels in GnRH neurons and/or to enhance (suppress) endogenous conductances (currents) including potassium (K ATP, A-type) and calcium low voltage T-type and high voltage L-type currents. Also, it is well documented that E2 can alter the excitability of GnRH neurons via direct action, but the intracellular signaling cascades mediating these actions are not well understood. As an example, KATP channels are critical ion channels needed for maintaining GnRH neurons in a hyperpolarized state for recruiting T-type calcium channels that are important for burst firing in GnRH neurons. E2 modulates the activity of KATP channels via a membrane-initiated signaling pathway in GnRH neurons. Obviously there are other channels, including the small conductance activated K + (SK) channels, that maybe modulated by this signaling pathway, but the ensemble of mER-, ERα-, and ERβ-mediated effects both pre- and post-synaptic will ultimately dictate the excitability of GnRH neurons.

Original languageEnglish (US)
Pages (from-to)25-34
Number of pages10
JournalBrain Research
Volume1364
DOIs
StatePublished - Dec 10 2010

Fingerprint

Gonadotropin-Releasing Hormone
Estrogens
Neurons
KATP Channels
Ion Channels
T-Type Calcium Channels
Estradiol
Potassium
Adenosine Triphosphate
Steroids
Hormones
Calcium
Messenger RNA
Membranes

Keywords

  • 17β-estradiol
  • Estrogen receptors
  • Excitability
  • Hyperpolarization
  • Ion channels

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Regulation of endogenous conductances in GnRH neurons by estrogens. / Ronnekleiv, Oline; Bosch, Martha A.; Zhang, Chunguang.

In: Brain Research, Vol. 1364, 10.12.2010, p. 25-34.

Research output: Contribution to journalArticle

Ronnekleiv, Oline ; Bosch, Martha A. ; Zhang, Chunguang. / Regulation of endogenous conductances in GnRH neurons by estrogens. In: Brain Research. 2010 ; Vol. 1364. pp. 25-34.
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