Regulation of DNA glycosylases and their role in limiting disease

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

This review will present a current understanding of mechanisms for the initiation of base excision repair (BER) of oxidatively-induced DNA damage and the biological consequences of deficiencies in these enzymes in mouse model systems and human populations.

Original languageEnglish (US)
Pages (from-to)460-478
Number of pages19
JournalFree Radical Research
Volume46
Issue number4
DOIs
StatePublished - Apr 2012

Fingerprint

DNA Glycosylases
DNA Repair
DNA Damage
Repair
DNA
Enzymes
Population

Keywords

  • Glycosylase-deficient mice
  • Metabolic disease
  • MUTYH
  • NEIL1,2,3
  • NTH1
  • OGG1

ASJC Scopus subject areas

  • Biochemistry

Cite this

Regulation of DNA glycosylases and their role in limiting disease. / Sampath, Harini; McCullough, Amanda; Lloyd, Robert (Stephen).

In: Free Radical Research, Vol. 46, No. 4, 04.2012, p. 460-478.

Research output: Contribution to journalArticle

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