Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

Matthew J. Simon, Jeffrey Iliff

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Cerebrospinal fluid (CSF) circulation and turnover provides a sink for the elimination of solutes from the brain interstitium, serving an important homeostatic role for the function of the central nervous system. Disruption of normal CSF circulation and turnover is believed to contribute to the development of many diseases, including neurodegenerative conditions such as Alzheimer's disease, ischemic and traumatic brain injury, and neuroinflammatory conditions such as multiple sclerosis. Recent insights into CSF biology suggesting that CSF and interstitial fluid exchange along a brain-wide network of perivascular spaces termed the 'glymphatic' system suggest that CSF circulation may interact intimately with glial and vascular function to regulate basic aspects of brain function. Dysfunction within this glial vascular network, which is a feature of the aging and injured brain, is a potentially critical link between brain injury, neuroinflammation and the development of chronic neurodegeneration. Ongoing research within this field may provide a powerful new framework for understanding the common links between neurodegenerative, neurovascular and neuroinflammatory disease, in addition to providing potentially novel therapeutic targets for these conditions. This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.

Original languageEnglish (US)
Pages (from-to)442-451
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1862
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Cerebrospinal Fluid
Brain
Neuroglia
Blood Vessels
Extracellular Fluid
Neurodegenerative Diseases
Brain Injuries
Multiple Sclerosis
Alzheimer Disease
Central Nervous System
Inflammation
Research
Therapeutics

Keywords

  • Alzheimer's disease
  • Cerebral ischemia
  • CSF
  • Diurnal variation
  • Glymphatic
  • Multiple sclerosis

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

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