Regulation of brain Ca2+/calmodulin-dependent protein kinase II.

Thomas Soderling, K. Fukunaga, D. P. Rich, Y. L. Fong, K. Smith, R. J. Colbran

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

CaM-kinase II is a multifunctional protein kinase highly enriched in neural tissues where it modulates a variety of Ca2(+)-dependent processes. A complex regulatory domain in the kinase within residues 281-309 contains an autoinhibitory sequence, a CaM-binding region, and sites of regulatory autophosphorylation. Autophosphorylation on Thr286 converts the kinase to a Ca2(+)-independent form which could prolong physiological systems controlled by this kinase in response to transient Ca2+ elevations. Such properties appear to exist in dynamic equilibrium in the isolated postsynaptic density and in cultured brain cells. These unique biochemical regulatory properties, coupled with an unusual high concentration in the postsynaptic density of excitatory synapses, makes CaM-kinase II an attractive candidate for involvement in synaptic plasticity.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalAdvances in second messenger and phosphoprotein research
Volume24
StatePublished - 1990
Externally publishedYes

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Calcium-Calmodulin-Dependent Protein Kinase Type 2
Post-Synaptic Density
Phosphotransferases
Brain
Neuronal Plasticity
Nucleic Acid Regulatory Sequences
Synapses
Protein Kinases
Cultured Cells
Binding Sites

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Soderling, T., Fukunaga, K., Rich, D. P., Fong, Y. L., Smith, K., & Colbran, R. J. (1990). Regulation of brain Ca2+/calmodulin-dependent protein kinase II. Advances in second messenger and phosphoprotein research, 24, 206-211.

Regulation of brain Ca2+/calmodulin-dependent protein kinase II. / Soderling, Thomas; Fukunaga, K.; Rich, D. P.; Fong, Y. L.; Smith, K.; Colbran, R. J.

In: Advances in second messenger and phosphoprotein research, Vol. 24, 1990, p. 206-211.

Research output: Contribution to journalArticle

Soderling, T, Fukunaga, K, Rich, DP, Fong, YL, Smith, K & Colbran, RJ 1990, 'Regulation of brain Ca2+/calmodulin-dependent protein kinase II.', Advances in second messenger and phosphoprotein research, vol. 24, pp. 206-211.
Soderling T, Fukunaga K, Rich DP, Fong YL, Smith K, Colbran RJ. Regulation of brain Ca2+/calmodulin-dependent protein kinase II. Advances in second messenger and phosphoprotein research. 1990;24:206-211.
Soderling, Thomas ; Fukunaga, K. ; Rich, D. P. ; Fong, Y. L. ; Smith, K. ; Colbran, R. J. / Regulation of brain Ca2+/calmodulin-dependent protein kinase II. In: Advances in second messenger and phosphoprotein research. 1990 ; Vol. 24. pp. 206-211.
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