Regulation of atrial natriuretic factor secretion and expression in the ovine fetus

Cecilia Cheung

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The cardiac hormone atrial natriuretic factor (ANF) is present in the fetal circulation at high concentrations and exceeds that in the maternal circulation. Administration of exogenous ANF into the near-term ovine fetus lowers arterial pressure and reduces blood volume. The fetal kidney responds to ANF with a diuresis and natriuresis. The physiological stimuli which modulate ANF secretion in the fetus include vascular volume expansion, hyperosmolality and hypoxia, with hypoxia being the most potent stimulus. In addition, endothelin administration into the fetus increases plasma ANF concentrations. The fetal atria appears to be the primary site of ANF synthesis, although the ventricles also produce ANF. The expression of ANF peptide and its messenger RNA in the fetal atria and ventricles demonstrate a developmental pattern. Thus, the secretion of ANF may be mediated by factors such as endothelin and may be augmented by stimuli such as hypoxia which acts through induction of cardiac ANF gene expression.

Original languageEnglish (US)
Pages (from-to)159-164
Number of pages6
JournalNeuroscience and Biobehavioral Reviews
Volume19
Issue number2
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Atrial Natriuretic Factor
Sheep
Fetus
Endothelins
Natriuresis
Diuresis
Blood Volume
Blood Vessels
Arterial Pressure
Mothers
Hormones
Kidney
Gene Expression
Messenger RNA

Keywords

  • Fetal development
  • Gene expression
  • Natriuretic factor

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Regulation of atrial natriuretic factor secretion and expression in the ovine fetus. / Cheung, Cecilia.

In: Neuroscience and Biobehavioral Reviews, Vol. 19, No. 2, 1995, p. 159-164.

Research output: Contribution to journalArticle

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