TY - JOUR
T1 - Regulation of acetylcholine receptor channel function during development of skeletal muscle
AU - Brehm, Paul
AU - Henderson, Leslie
N1 - Funding Information:
In writing this review we would like to acknowledge the late Dr. Stephen M. Schuetze who contributed so significantly to this field. His insights and input as a colleague, and as a friend, will be greatly missed. Support for the preparation of this manuscript was provided by an NIH postdoctoral fellowship to L.P.H. and a grant from the NIH to P.B.
PY - 1988/9
Y1 - 1988/9
N2 - The nicotinic acetylcholine (ACh) receptor channel mediates synaptic transmission at the neuromuscular junction. During the development of skeletal muscle, ACh receptors undergo changes in distribution, antigenic determinants, degradation rate, and function. Now that these developmental hallmarks have been identified, attention has turned toward understanding both the structural bases for such changes and the role of nerve in triggering these changes. Recently, a much clearer understanding of one of these developmental processes, namely, the alterations in channel function, has emerged through both sensitive patch-clamp measurements and the application of recombinant DNA technology. In light of these new advances, we now reevaluate the processes governing the developmental changes in the functional properties of the ACh receptor.
AB - The nicotinic acetylcholine (ACh) receptor channel mediates synaptic transmission at the neuromuscular junction. During the development of skeletal muscle, ACh receptors undergo changes in distribution, antigenic determinants, degradation rate, and function. Now that these developmental hallmarks have been identified, attention has turned toward understanding both the structural bases for such changes and the role of nerve in triggering these changes. Recently, a much clearer understanding of one of these developmental processes, namely, the alterations in channel function, has emerged through both sensitive patch-clamp measurements and the application of recombinant DNA technology. In light of these new advances, we now reevaluate the processes governing the developmental changes in the functional properties of the ACh receptor.
UR - http://www.scopus.com/inward/record.url?scp=0023718411&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023718411&partnerID=8YFLogxK
U2 - 10.1016/0012-1606(88)90156-X
DO - 10.1016/0012-1606(88)90156-X
M3 - Review article
C2 - 2457524
AN - SCOPUS:0023718411
SN - 0012-1606
VL - 129
SP - 1
EP - 11
JO - Developmental Biology
JF - Developmental Biology
IS - 1
ER -