Regular alcohol consumption mimics cardiac preconditioning by protecting against ischemia-reperfusion injury

Masami Miyamae, Ivan Diamond, Michael W. Weiner, S. Albert Camacho, Vincent M. Figueredo

Research output: Contribution to journalArticlepeer-review

90 Scopus citations

Abstract

Epidemiologic studies indicate that long-term alcohol consumption decreases the incidence of coronary disease and may improve outcome after myocardial infarction. Attenuation of ischemia-reperfusion injury after myocardial infarction improves survival. This study investigates the possibility that alcohol consumption can improve survival after myocardial infarction by reducing ischemia-reperfusion injury. Hearts were isolated from guinea pigs after drinking ethanol for 3-12 weeks and subjected to global ischemia and reperfusion. Hearts from animals drinking ethanol showed improved functional recovery and decreased myocyte damage when compared with controls. Adenosine A1 receptor blockade abolished the protection provided by ethanol consumption. These findings indicate that long-term alcohol consumption reduces myocardial ischemia-reperfusion injury and that adenosine A1 receptors are required for this protective effect of ethanol. This cardioprotective effect of long-term alcohol consumption mimics preconditioning and may, in part, account for the beneficial effect of moderate drinking on cardiac health.

Original languageEnglish (US)
Pages (from-to)3235-3239
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume94
Issue number7
DOIs
StatePublished - Apr 1 1997
Externally publishedYes

Keywords

  • adenosine
  • ethanol
  • guinea pig
  • heart
  • myocardial infarction

ASJC Scopus subject areas

  • General

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