Regioselective Synthesis of Inositol Phosphate Diesters via a Cyclic Phosphate Triester Approach

Carsten Schultz, Thomas Metschies, Benjamin Gerlach, Christoph Stadler, Bernd Jastorff

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Phosphate-substituted analogues of myo-inositol 1-phosphate and 2-phosphate were synthesized by a novel method via a five-membered cyclic phosphate triester intermediate, which was cleaved regioselectively by various alcohols. Low temperatures and bulky alcohols gave higher selectivity for myo-inositol 1-phosphate alkyl esters. Addition of sodium sulfite to the reaction mixture yielded predominantly the 2-phosphate diester.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalSynlett
Volume1990
Issue number3
DOIs
StatePublished - Mar 1990

ASJC Scopus subject areas

  • Organic Chemistry

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