Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging

Ramon Barajas, Joanna J. Phillips, Rupa Parvataneni, Annette Molinaro, Emma Essock-Burns, Gabriela Bourne, Andrew T. Parsa, Manish K. Aghi, Michael W. McDermott, Mitchel S. Berger, Soonmee Cha, Susan M. Chang, Sarah J. Nelson

Research output: Contribution to journalArticle

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Abstract

Histopathologic evaluation of glioblastoma multiforme (GBM) at initial diagnosis is typically performed on tissue obtained from regions of contrast enhancement (CE) as depicted on gadolinium-enhanced, T1-weighted images. The non-enhancing (NE) portion of the lesion, which contains both reactive edema and infiltrative tumor, is only partially removed due to concerns about damaging functioning brain. The purpose of this study was to evaluate histopathologic and physiologic MRI features of image-guided tissue specimens from CE and NE regions to investigate correlations between imaging and histopathologic parameters. One hundred nineteen tissue specimens (93 CE and 26 NE regions) were acquired from 51 patients with newly diagnosed GBM by utilizing stereotactic image-guided sampling. Variables of anatomic, diffusion-weighted imaging (DWI), and dynamic susceptibilityweighted, contrast-enhanced perfusion imaging (DSC) from each tissue sample location were obtained and compared with histopathologic features such as tumor score, cell density, proliferation, architectural disruption, hypoxia, and microvascular hyperplasia. Tissue samples from CE regions had increased tumor score, cellular density, proliferation, and architectural disruption compared with NE regions. DSC variables such as relative cerebral blood volume, peak height, and recovery factor were significantly higher, and the percentage of signal intensity recovery was significantly lower in the CE compared with the NE regions. DWI variables were correlated with histopathologic features of GBM within NE regions. Image-guided tissue acquisition and assessment of residual tumor from treatment-naive GBM should be guided by DSC in CE regions and by DWI in NE regions.

Original languageEnglish (US)
Pages (from-to)942-954
Number of pages13
JournalNeuro-Oncology
Volume14
Issue number7
DOIs
StatePublished - Jul 2012
Externally publishedYes

Fingerprint

Glioblastoma
Neoplasms
Therapeutics
Cell Proliferation
Perfusion Imaging
Gadolinium
Residual Neoplasm
Hyperplasia
Edema
Cell Count
Brain

Keywords

  • diffusion-weighted imaging
  • dynamic susceptibility contrast-enhanced imaging
  • glioblastoma
  • image-guided tissue acquisition
  • magnetic resonance imaging

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Clinical Neurology

Cite this

Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. / Barajas, Ramon; Phillips, Joanna J.; Parvataneni, Rupa; Molinaro, Annette; Essock-Burns, Emma; Bourne, Gabriela; Parsa, Andrew T.; Aghi, Manish K.; McDermott, Michael W.; Berger, Mitchel S.; Cha, Soonmee; Chang, Susan M.; Nelson, Sarah J.

In: Neuro-Oncology, Vol. 14, No. 7, 07.2012, p. 942-954.

Research output: Contribution to journalArticle

Barajas, R, Phillips, JJ, Parvataneni, R, Molinaro, A, Essock-Burns, E, Bourne, G, Parsa, AT, Aghi, MK, McDermott, MW, Berger, MS, Cha, S, Chang, SM & Nelson, SJ 2012, 'Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging', Neuro-Oncology, vol. 14, no. 7, pp. 942-954. https://doi.org/10.1093/neuonc/nos128
Barajas, Ramon ; Phillips, Joanna J. ; Parvataneni, Rupa ; Molinaro, Annette ; Essock-Burns, Emma ; Bourne, Gabriela ; Parsa, Andrew T. ; Aghi, Manish K. ; McDermott, Michael W. ; Berger, Mitchel S. ; Cha, Soonmee ; Chang, Susan M. ; Nelson, Sarah J. / Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. In: Neuro-Oncology. 2012 ; Vol. 14, No. 7. pp. 942-954.
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AU - Phillips, Joanna J.

AU - Parvataneni, Rupa

AU - Molinaro, Annette

AU - Essock-Burns, Emma

AU - Bourne, Gabriela

AU - Parsa, Andrew T.

AU - Aghi, Manish K.

AU - McDermott, Michael W.

AU - Berger, Mitchel S.

AU - Cha, Soonmee

AU - Chang, Susan M.

AU - Nelson, Sarah J.

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