Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: Influence of estradiol

Steven G. Kohama; Vasilios T. Garyfallou; Henryk F. Urbanski

doi:10.1016/S0169-328X(97)00282-9

Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: Influence of estradiol

Steven G. Kohama, Vasilios T. Garyfallou, Henryk F. Urbanski

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The distribution of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.

Original language	English (US)
Pages (from-to)	328-332
Number of pages	5
Journal	Molecular Brain Research
Volume	53
Issue number	1-2
DOIs	https://doi.org/10.1016/S0169-328X(97)00282-9
State	Published - Jan 1998

Keywords

AMPA
In situ hybridization
NMDA

ASJC Scopus subject areas

Molecular Biology
Cellular and Molecular Neuroscience

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10.1016/S0169-328X(97)00282-9

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title = "Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: Influence of estradiol",

abstract = "The distribution of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.",

keywords = "AMPA, In situ hybridization, NMDA",

author = "Kohama, {Steven G.} and Garyfallou, {Vasilios T.} and Urbanski, {Henryk F.}",

note = "Funding Information: The authors would like to thank Shigetada Nakanishi (Kyoto University, Kyoto, Japan) and Michael Hollmann (Salk Institute, La Jolla, CA) for the donation of the NR1, GluR1 and GluR2 cDNAs, respectively. The kind assistance of Jared Cooper with tissue sectioning was also greatly appreciated. This research was supported by the Alzheimer's Association/Ogilvy and Mather Research Grant and the National Institutes of Health (HD-29186, HD-18185 and RR-00163).",

year = "1998",

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doi = "10.1016/S0169-328X(97)00282-9",

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volume = "53",

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T1 - Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex

T2 - Influence of estradiol

AU - Kohama, Steven G.

AU - Garyfallou, Vasilios T.

AU - Urbanski, Henryk F.

N1 - Funding Information: The authors would like to thank Shigetada Nakanishi (Kyoto University, Kyoto, Japan) and Michael Hollmann (Salk Institute, La Jolla, CA) for the donation of the NR1, GluR1 and GluR2 cDNAs, respectively. The kind assistance of Jared Cooper with tissue sectioning was also greatly appreciated. This research was supported by the Alzheimer's Association/Ogilvy and Mather Research Grant and the National Institutes of Health (HD-29186, HD-18185 and RR-00163).

PY - 1998/1

Y1 - 1998/1

N2 - The distribution of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.

AB - The distribution of N-methyl-D-aspartate (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) glutamate receptor subunits was examined in the hippocampus and temporal cortex of adult ovariectomized female rhesus macaques, some of which received estradiol replacement. In situ hybridization revealed a generalized overlap of NR1, GluR1, and GluR2 subunit mRNAs, but no effect due to estradiol treatment. However, regional differences in expression were noted for each subunit.

KW - AMPA

KW - In situ hybridization

KW - NMDA

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JF - Brain Research

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Regional distribution of glutamate receptor mRNA in the monkey hippocampus and temporal cortex: Influence of estradiol

Abstract

Keywords

ASJC Scopus subject areas

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