Regional distribution of blood flow during mild dynamic leg exercise in the baboon

Alan (Roger) Hohimer, J. R. Hales, L. B. Rowell, O. A. Smith

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Five chair-restrained baboons were trained with operant techniques and a food reward to perform dynamic leg exercise. Cardiac output and blood flows to most tissues were determined by radioactive microsphere distribution. After 2 min of exercise mean arterial blood pressure had increased by 11 ± 3% (SE), heart rate by 34 ± 7%, cardiac output by 50 ± 12%, and O2 consumption by 157 ± 17%. The blood flow to exercising leg muscle increased by 585 ± 338% and to the myocardium by 35 ± 19%. Blood flow to torso and limb skin fell by 38 ± 4 and 38 ± 6%, respectively, and similar reductions occurred in adipose tissue blood flow. Nonworking skeletal muscle blood flow decreased by 30 ± 10%. Renal blood flow was lowered by 16 ± 2%. The lower visceral organs had more variable responses, but when grouped together total splanchnic blood flow fell by 21 ± 9%. Blood flow to the brain was unchanged with exercise, whereas spinal cord perfusion increased 23 ± 3%. Thus during short dynamic exercise baboons redistributed blood flow away from skin, fat, nonworking muscles, and visceral organs to supply the needs of exercising muscles. Our data suggest the baboon is a useful animal model for investigating vascular responses of tissues, such as torso skin, adipose, individual visceral organs, and the spinal cord, that cannot be examined in humans.

Original languageEnglish (US)
Pages (from-to)1173-1177
Number of pages5
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume55
Issue number4
StatePublished - 1983
Externally publishedYes

Fingerprint

Papio
Regional Blood Flow
Leg
Torso
Cardiac Output
Muscles
Skin
Spinal Cord
Arterial Pressure
Viscera
Renal Circulation
Microspheres
Reward
Blood Vessels
Adipose Tissue
Myocardium
Skeletal Muscle
Extremities
Animal Models
Perfusion

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Regional distribution of blood flow during mild dynamic leg exercise in the baboon. / Hohimer, Alan (Roger); Hales, J. R.; Rowell, L. B.; Smith, O. A.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 55, No. 4, 1983, p. 1173-1177.

Research output: Contribution to journalArticle

Hohimer, Alan (Roger) ; Hales, J. R. ; Rowell, L. B. ; Smith, O. A. / Regional distribution of blood flow during mild dynamic leg exercise in the baboon. In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology. 1983 ; Vol. 55, No. 4. pp. 1173-1177.
@article{5a657c3a41f84990a2af8ace2987fc3d,
title = "Regional distribution of blood flow during mild dynamic leg exercise in the baboon",
abstract = "Five chair-restrained baboons were trained with operant techniques and a food reward to perform dynamic leg exercise. Cardiac output and blood flows to most tissues were determined by radioactive microsphere distribution. After 2 min of exercise mean arterial blood pressure had increased by 11 ± 3{\%} (SE), heart rate by 34 ± 7{\%}, cardiac output by 50 ± 12{\%}, and O2 consumption by 157 ± 17{\%}. The blood flow to exercising leg muscle increased by 585 ± 338{\%} and to the myocardium by 35 ± 19{\%}. Blood flow to torso and limb skin fell by 38 ± 4 and 38 ± 6{\%}, respectively, and similar reductions occurred in adipose tissue blood flow. Nonworking skeletal muscle blood flow decreased by 30 ± 10{\%}. Renal blood flow was lowered by 16 ± 2{\%}. The lower visceral organs had more variable responses, but when grouped together total splanchnic blood flow fell by 21 ± 9{\%}. Blood flow to the brain was unchanged with exercise, whereas spinal cord perfusion increased 23 ± 3{\%}. Thus during short dynamic exercise baboons redistributed blood flow away from skin, fat, nonworking muscles, and visceral organs to supply the needs of exercising muscles. Our data suggest the baboon is a useful animal model for investigating vascular responses of tissues, such as torso skin, adipose, individual visceral organs, and the spinal cord, that cannot be examined in humans.",
author = "Hohimer, {Alan (Roger)} and Hales, {J. R.} and Rowell, {L. B.} and Smith, {O. A.}",
year = "1983",
language = "English (US)",
volume = "55",
pages = "1173--1177",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "4",

}

TY - JOUR

T1 - Regional distribution of blood flow during mild dynamic leg exercise in the baboon

AU - Hohimer, Alan (Roger)

AU - Hales, J. R.

AU - Rowell, L. B.

AU - Smith, O. A.

PY - 1983

Y1 - 1983

N2 - Five chair-restrained baboons were trained with operant techniques and a food reward to perform dynamic leg exercise. Cardiac output and blood flows to most tissues were determined by radioactive microsphere distribution. After 2 min of exercise mean arterial blood pressure had increased by 11 ± 3% (SE), heart rate by 34 ± 7%, cardiac output by 50 ± 12%, and O2 consumption by 157 ± 17%. The blood flow to exercising leg muscle increased by 585 ± 338% and to the myocardium by 35 ± 19%. Blood flow to torso and limb skin fell by 38 ± 4 and 38 ± 6%, respectively, and similar reductions occurred in adipose tissue blood flow. Nonworking skeletal muscle blood flow decreased by 30 ± 10%. Renal blood flow was lowered by 16 ± 2%. The lower visceral organs had more variable responses, but when grouped together total splanchnic blood flow fell by 21 ± 9%. Blood flow to the brain was unchanged with exercise, whereas spinal cord perfusion increased 23 ± 3%. Thus during short dynamic exercise baboons redistributed blood flow away from skin, fat, nonworking muscles, and visceral organs to supply the needs of exercising muscles. Our data suggest the baboon is a useful animal model for investigating vascular responses of tissues, such as torso skin, adipose, individual visceral organs, and the spinal cord, that cannot be examined in humans.

AB - Five chair-restrained baboons were trained with operant techniques and a food reward to perform dynamic leg exercise. Cardiac output and blood flows to most tissues were determined by radioactive microsphere distribution. After 2 min of exercise mean arterial blood pressure had increased by 11 ± 3% (SE), heart rate by 34 ± 7%, cardiac output by 50 ± 12%, and O2 consumption by 157 ± 17%. The blood flow to exercising leg muscle increased by 585 ± 338% and to the myocardium by 35 ± 19%. Blood flow to torso and limb skin fell by 38 ± 4 and 38 ± 6%, respectively, and similar reductions occurred in adipose tissue blood flow. Nonworking skeletal muscle blood flow decreased by 30 ± 10%. Renal blood flow was lowered by 16 ± 2%. The lower visceral organs had more variable responses, but when grouped together total splanchnic blood flow fell by 21 ± 9%. Blood flow to the brain was unchanged with exercise, whereas spinal cord perfusion increased 23 ± 3%. Thus during short dynamic exercise baboons redistributed blood flow away from skin, fat, nonworking muscles, and visceral organs to supply the needs of exercising muscles. Our data suggest the baboon is a useful animal model for investigating vascular responses of tissues, such as torso skin, adipose, individual visceral organs, and the spinal cord, that cannot be examined in humans.

UR - http://www.scopus.com/inward/record.url?scp=0020521215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020521215&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 1173

EP - 1177

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 4

ER -