Regional anthropometry changes in antiretroviral-naïve persons initiating a zidovudine-containing regimen in Mbarara, Uganda

Vanessa Thompson, Bitekyerezo Medard, Kabanda Taseera, Ali J. Chakera, Irene Andia, Nneka Emenyonu, Peter W. Hunt, Jeffrey Martin, Rebecca Scherzer, Sheri D. Weiser, David Bangsberg, Phyllis C. Tien

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Lipodystrophy is commonly reported in Africa after antiretroviral therapy (ART) is initiated, but few studies have objectively measured changes in body composition. Body composition was determined in 76 HIV-infected participants from Mbarara, Uganda after starting a thymidine-analog regimen, and annual change was determined using repeated measures analysis. We measured skinfolds (tricep, thigh, subscapular, and abdomen), circumferences (arm, hip, thigh, waist), and total lean and fat mass (using bioelectric impedance analysis). A cross-sectional sample of 49 HIV-uninfected participants was studied for comparison. At baseline, most body composition measures were lower in HIV-infected than uninfected participants, but waist circumference was similar. After 12 months on ART, there was little difference in body composition measures between HIV-infected and uninfected participants; median waist circumference appeared higher in HIV-infected participants (79 vs. 75cm; p=0.090). Among HIV-infected participants, increases were observed in total lean and fat mass, circumference, and skinfold measures; only the increase in tricep skinfold did not reach statistical significance (+1.05mm; 95% confidence interval:-0.24, 2.34; p=0.11). Regional anthropometry in peripheral and central body sites increased over 12 months after ART initiation in HIV-infected persons from southwestern Uganda, suggesting a restoration to health. Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery.

Original languageEnglish (US)
Pages (from-to)785-791
Number of pages7
JournalAIDS Research and Human Retroviruses
Volume27
Issue number7
DOIs
StatePublished - Jul 1 2011
Externally publishedYes

Fingerprint

Anthropometry
Uganda
Zidovudine
HIV
Body Composition
Body Weights and Measures
Subcutaneous Fat
Waist Circumference
Thigh
Fats
Lipodystrophy
Electric Impedance
Abdomen
Thymidine
Hip
Arm
Therapeutics
Confidence Intervals
Health

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

Cite this

Regional anthropometry changes in antiretroviral-naïve persons initiating a zidovudine-containing regimen in Mbarara, Uganda. / Thompson, Vanessa; Medard, Bitekyerezo; Taseera, Kabanda; Chakera, Ali J.; Andia, Irene; Emenyonu, Nneka; Hunt, Peter W.; Martin, Jeffrey; Scherzer, Rebecca; Weiser, Sheri D.; Bangsberg, David; Tien, Phyllis C.

In: AIDS Research and Human Retroviruses, Vol. 27, No. 7, 01.07.2011, p. 785-791.

Research output: Contribution to journalArticle

Thompson, V, Medard, B, Taseera, K, Chakera, AJ, Andia, I, Emenyonu, N, Hunt, PW, Martin, J, Scherzer, R, Weiser, SD, Bangsberg, D & Tien, PC 2011, 'Regional anthropometry changes in antiretroviral-naïve persons initiating a zidovudine-containing regimen in Mbarara, Uganda', AIDS Research and Human Retroviruses, vol. 27, no. 7, pp. 785-791. https://doi.org/10.1089/aid.2010.0272
Thompson, Vanessa ; Medard, Bitekyerezo ; Taseera, Kabanda ; Chakera, Ali J. ; Andia, Irene ; Emenyonu, Nneka ; Hunt, Peter W. ; Martin, Jeffrey ; Scherzer, Rebecca ; Weiser, Sheri D. ; Bangsberg, David ; Tien, Phyllis C. / Regional anthropometry changes in antiretroviral-naïve persons initiating a zidovudine-containing regimen in Mbarara, Uganda. In: AIDS Research and Human Retroviruses. 2011 ; Vol. 27, No. 7. pp. 785-791.
@article{023df3f1d1824a9bac8caa6dfa9c6e72,
title = "Regional anthropometry changes in antiretroviral-na{\"i}ve persons initiating a zidovudine-containing regimen in Mbarara, Uganda",
abstract = "Lipodystrophy is commonly reported in Africa after antiretroviral therapy (ART) is initiated, but few studies have objectively measured changes in body composition. Body composition was determined in 76 HIV-infected participants from Mbarara, Uganda after starting a thymidine-analog regimen, and annual change was determined using repeated measures analysis. We measured skinfolds (tricep, thigh, subscapular, and abdomen), circumferences (arm, hip, thigh, waist), and total lean and fat mass (using bioelectric impedance analysis). A cross-sectional sample of 49 HIV-uninfected participants was studied for comparison. At baseline, most body composition measures were lower in HIV-infected than uninfected participants, but waist circumference was similar. After 12 months on ART, there was little difference in body composition measures between HIV-infected and uninfected participants; median waist circumference appeared higher in HIV-infected participants (79 vs. 75cm; p=0.090). Among HIV-infected participants, increases were observed in total lean and fat mass, circumference, and skinfold measures; only the increase in tricep skinfold did not reach statistical significance (+1.05mm; 95{\%} confidence interval:-0.24, 2.34; p=0.11). Regional anthropometry in peripheral and central body sites increased over 12 months after ART initiation in HIV-infected persons from southwestern Uganda, suggesting a restoration to health. Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery.",
author = "Vanessa Thompson and Bitekyerezo Medard and Kabanda Taseera and Chakera, {Ali J.} and Irene Andia and Nneka Emenyonu and Hunt, {Peter W.} and Jeffrey Martin and Rebecca Scherzer and Weiser, {Sheri D.} and David Bangsberg and Tien, {Phyllis C.}",
year = "2011",
month = "7",
day = "1",
doi = "10.1089/aid.2010.0272",
language = "English (US)",
volume = "27",
pages = "785--791",
journal = "AIDS Research and Human Retroviruses",
issn = "0889-2229",
publisher = "Mary Ann Liebert Inc.",
number = "7",

}

TY - JOUR

T1 - Regional anthropometry changes in antiretroviral-naïve persons initiating a zidovudine-containing regimen in Mbarara, Uganda

AU - Thompson, Vanessa

AU - Medard, Bitekyerezo

AU - Taseera, Kabanda

AU - Chakera, Ali J.

AU - Andia, Irene

AU - Emenyonu, Nneka

AU - Hunt, Peter W.

AU - Martin, Jeffrey

AU - Scherzer, Rebecca

AU - Weiser, Sheri D.

AU - Bangsberg, David

AU - Tien, Phyllis C.

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Lipodystrophy is commonly reported in Africa after antiretroviral therapy (ART) is initiated, but few studies have objectively measured changes in body composition. Body composition was determined in 76 HIV-infected participants from Mbarara, Uganda after starting a thymidine-analog regimen, and annual change was determined using repeated measures analysis. We measured skinfolds (tricep, thigh, subscapular, and abdomen), circumferences (arm, hip, thigh, waist), and total lean and fat mass (using bioelectric impedance analysis). A cross-sectional sample of 49 HIV-uninfected participants was studied for comparison. At baseline, most body composition measures were lower in HIV-infected than uninfected participants, but waist circumference was similar. After 12 months on ART, there was little difference in body composition measures between HIV-infected and uninfected participants; median waist circumference appeared higher in HIV-infected participants (79 vs. 75cm; p=0.090). Among HIV-infected participants, increases were observed in total lean and fat mass, circumference, and skinfold measures; only the increase in tricep skinfold did not reach statistical significance (+1.05mm; 95% confidence interval:-0.24, 2.34; p=0.11). Regional anthropometry in peripheral and central body sites increased over 12 months after ART initiation in HIV-infected persons from southwestern Uganda, suggesting a restoration to health. Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery.

AB - Lipodystrophy is commonly reported in Africa after antiretroviral therapy (ART) is initiated, but few studies have objectively measured changes in body composition. Body composition was determined in 76 HIV-infected participants from Mbarara, Uganda after starting a thymidine-analog regimen, and annual change was determined using repeated measures analysis. We measured skinfolds (tricep, thigh, subscapular, and abdomen), circumferences (arm, hip, thigh, waist), and total lean and fat mass (using bioelectric impedance analysis). A cross-sectional sample of 49 HIV-uninfected participants was studied for comparison. At baseline, most body composition measures were lower in HIV-infected than uninfected participants, but waist circumference was similar. After 12 months on ART, there was little difference in body composition measures between HIV-infected and uninfected participants; median waist circumference appeared higher in HIV-infected participants (79 vs. 75cm; p=0.090). Among HIV-infected participants, increases were observed in total lean and fat mass, circumference, and skinfold measures; only the increase in tricep skinfold did not reach statistical significance (+1.05mm; 95% confidence interval:-0.24, 2.34; p=0.11). Regional anthropometry in peripheral and central body sites increased over 12 months after ART initiation in HIV-infected persons from southwestern Uganda, suggesting a restoration to health. Gains in the tricep skinfold, a reliable marker of subcutaneous fat, appeared blunted, which could indicate an inhibitory effect of zidovudine on peripheral subcutaneous fat recovery.

UR - http://www.scopus.com/inward/record.url?scp=79959835844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79959835844&partnerID=8YFLogxK

U2 - 10.1089/aid.2010.0272

DO - 10.1089/aid.2010.0272

M3 - Article

C2 - 21128866

AN - SCOPUS:79959835844

VL - 27

SP - 785

EP - 791

JO - AIDS Research and Human Retroviruses

JF - AIDS Research and Human Retroviruses

SN - 0889-2229

IS - 7

ER -