Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus

H. Rigter, R. B. Messing, B. J. Vasquez, R. A. Jensen, J. L. Martinez, J. C. Crabbe, J. L. McGaugh

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides.

Original languageEnglish (US)
Pages (from-to)1137-1143
Number of pages7
JournalLife Sciences
Volume25
Issue number13
DOIs
StatePublished - Sep 24 1979

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Rigter, H., Messing, R. B., Vasquez, B. J., Jensen, R. A., Martinez, J. L., Crabbe, J. C., & McGaugh, J. L. (1979). Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus. Life Sciences, 25(13), 1137-1143. https://doi.org/10.1016/0024-3205(79)90135-8