Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus

H. Rigter; R. B. Messing; B. J. Vasquez; R. A. Jensen; J. L. Martinez; J. C. Crabbe; J. L. McGaugh

doi:10.1016/0024-3205(79)90135-8

Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus

H. Rigter, R. B. Messing, B. J. Vasquez, R. A. Jensen, J. L. Martinez, J. C. Crabbe, J. L. McGaugh

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The regional distribution of stereospecific ³H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of ³H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides.

Original language	English (US)
Pages (from-to)	1137-1143
Number of pages	7
Journal	Life Sciences
Volume	25
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(79)90135-8
State	Published - Sep 24 1979
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(79)90135-8

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title = "Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus",

abstract = "The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides.",

author = "H. Rigter and Messing, {R. B.} and Vasquez, {B. J.} and Jensen, {R. A.} and Martinez, {J. L.} and Crabbe, {J. C.} and McGaugh, {J. L.}",

note = "Funding Information: Supported by USPHS Grants AGO0538 and MH12526, NSF Grant BNS 76-17370, a grant from the McKnight Foundation (all to J . L. McG), the Organon International B .V . (H .R .) and USPHS Postdoctoral Fellowship MH05358 (R .A .J .) .",

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doi = "10.1016/0024-3205(79)90135-8",

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T1 - Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus

AU - Rigter, H.

AU - Messing, R. B.

AU - Vasquez, B. J.

AU - Jensen, R. A.

AU - Martinez, J. L.

AU - Crabbe, J. C.

AU - McGaugh, J. L.

N1 - Funding Information: Supported by USPHS Grants AGO0538 and MH12526, NSF Grant BNS 76-17370, a grant from the McKnight Foundation (all to J . L. McG), the Organon International B .V . (H .R .) and USPHS Postdoctoral Fellowship MH05358 (R .A .J .) .

PY - 1979/9/24

Y1 - 1979/9/24

N2 - The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides.

AB - The regional distribution of stereospecific 3H-dihydromorphine binding sites in Brattleboro rats with hereditary hypothalamic diabetes insipidus was studied. Control animals were homozygous normal Brattleboro rats and rats heterozygous for the vasopressin deficiency. Scatchard plots of 3H-dihydromorphine binding in a washed membrane preparation showed that rats with diabetes insipidus exhibited higher receptor concentrations in all assayed areas of the cerebral hemispheres. In the diencephalon, receptor concentrations were lower in diabetes insipidus rats. The results point to the existence of interactions between brain opioid systems and neurohypophyseal peptides.

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ER -

Regional analysis of brain opiate receptors in rats with hereditary hypothalamic diabetes insipidus

Abstract

ASJC Scopus subject areas

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