Reflex carotid body chemoreceptor control of phrenic sympathetic neurons

Agnieszka Balkowiec, S. Revenko, P. Szulczyk

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The reflexes reaction of phrenic sympathetic neurons to stimulation of carotid body chemoreceptors we tested in chloralos-anaesthetized and paralyzed cats with both vago-aotic nerves cut. During systemic hypoxia (animals ventilated with 10%2 in O_2 in N2) the sympathsti phrenic nerve activity increased from 100% in the control to 269%. The increase was markedly attentuad after cutting both nerves, Reflex exciatotry response in phrenic sympathetic neurons with the latency of 150 msec was evoked by electrical stimulation of the right carotid sinus nerve (3 pulses of 0.2 msec, 333 Hz). The central transmission time of the reflex was about 90 msec. Injecting 0.1 ml of 1 M NaHCO3 saturated with CO2 (in order to activate carotid body chemoreceptors) into the right or left carotid sinus, evoked excitatory responses in sympathetic neuronsp regardless of the side. The stimulation of carotid body chemoreceptors also increased somatic phrenic nerve activity. The three methods applied to the stimulation of carotid body chemoreceptors produced increase of phrenic nerve sympathetic activity.

Original languageEnglish (US)
Pages (from-to)91-100
Number of pages10
JournalRespiration Physiology
Volume92
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Carotid Body
Diaphragm
Phrenic Nerve
Reflex
Neurons
Carotid Sinus
Electric Stimulation
Cats

Keywords

  • Chemoreceptors, reflex, phrenic sympathetic neuros
  • Hypoxia
  • Mammals, cat
  • Neurons, phrenic sympathetic, p, chemoreceptors

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Reflex carotid body chemoreceptor control of phrenic sympathetic neurons. / Balkowiec, Agnieszka; Revenko, S.; Szulczyk, P.

In: Respiration Physiology, Vol. 92, No. 1, 1993, p. 91-100.

Research output: Contribution to journalArticle

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