Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, Alfred Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Most of the optical coherence tomographic (OCT) systems for high resolution imaging of biological specimens are based on refractive type microscope objectives, which are optimized for specific wave length of the optical source. In this study, we present the feasibility of using commercially available reflective type objective for high sensitive and high resolution structural and functional imaging of cochlear microstructures of an excised guinea pig through intact temporal bone. Unlike conventional refractive type microscopic objective, reflective objective are free from chromatic aberrations due to their all-reflecting nature and can support a broadband of spectrum with very high light collection efficiency.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8571
DOIs
StatePublished - 2013
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII - San Francisco, CA, United States
Duration: Feb 4 2013Feb 6 2013

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
CountryUnited States
CitySan Francisco, CA
Period2/4/132/6/13

Fingerprint

guinea pigs
cochlea
Temporal Bone
Optical tomography
Cochlea
Optical Coherence Tomography
bones
Bone
Guinea Pigs
Color
tomography
Imaging techniques
Light
Bone and Bones
microstructure
Microstructure
high resolution
Aberrations
Light sources
aberration

Keywords

  • biomedical optical imaging
  • hearing research
  • image processing
  • optical interferometry
  • optical vibrometry
  • Phase-sensitive Optical coherence tomography
  • reflective objective
  • spectral interferometry

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea. / Subhash, Hrebesh M.; Wang, Ruikang K.; Chen, Fangyi; Nuttall, Alfred.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8571 2013. 85713G.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Subhash, HM, Wang, RK, Chen, F & Nuttall, A 2013, Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 8571, 85713G, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII, San Francisco, CA, United States, 2/4/13. https://doi.org/10.1117/12.2002540
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