Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea

Hrebesh M. Subhash, Ruikang K. Wang, Fangyi Chen, Alfred L. Nuttall

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Most of the optical coherence tomographic (OCT) systems for high resolution imaging of biological specimens are based on refractive type microscope objectives, which are optimized for specific wave length of the optical source. In this study, we present the feasibility of using commercially available reflective type objective for high sensitive and high resolution structural and functional imaging of cochlear microstructures of an excised guinea pig through intact temporal bone. Unlike conventional refractive type microscopic objective, reflective objective are free from chromatic aberrations due to their all-reflecting nature and can support a broadband of spectrum with very high light collection efficiency.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
DOIs
StatePublished - May 22 2013
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII - San Francisco, CA, United States
Duration: Feb 4 2013Feb 6 2013

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume8571
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII
CountryUnited States
CitySan Francisco, CA
Period2/4/132/6/13

Keywords

  • Phase-sensitive Optical coherence tomography
  • biomedical optical imaging
  • hearing research
  • image processing
  • optical interferometry
  • optical vibrometry
  • reflective objective
  • spectral interferometry

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Subhash, H. M., Wang, R. K., Chen, F., & Nuttall, A. L. (2013). Reflective type objective based spectral-domain phase-sensitive optical coherence tomography for high-sensitive structural and functional imaging of cochlear microstructures through intact bone of an excised guinea pig cochlea. In Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVII [85713G] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 8571). https://doi.org/10.1117/12.2002540