Reflectance-based projection-resolved optical coherence tomography angiography [invited]

Jie Wang, Miao Zhang, Thomas S. Hwang, Steven T. Bailey, David Huang, David J. Wilson, Yali Jia

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Optical coherence tomography angiography (OCTA) is limited by projection artifacts from the superficial blood vessels onto deeper layers. We have recently described projection-resolved (PR) OCTA that solves the ambiguity between in situ flow and flow projection along each axial scan and suppresses the artifact on both en face and crosssectional angiograms. While this method significantly improved the depth resolution of OCTA, the vascular integrity of the deeper layers was not fully preserved. In this study, we propose a novel reflectance-based projection-resolved (rbPR) OCTA algorithm which uses OCT reflectance to enhance the flow signal and suppress the projection artifacts in 3dimensional OCTA. We demonstrated quantitatively that rbPR improved the vascular connectivity and improved the discrimination of the deeper plexus angiograms in healthy eyes, compared to prior PR-OCTA method. We also demonstrated qualitatively that rbPR removes flow projection artifacts more completely from the outer retinal slab in the eyes with age-related macular degeneration, and preserves vascular integrity of the intermediate and deep capillary plexuses in the eyes with diabetic retinopathy. Additionally, this method improves the resolution of the choriocapillaris and demonstrates details comparable to scanning electron microscopy.

Original languageEnglish (US)
Article number#280399
Pages (from-to)1536-1548
Number of pages13
JournalBiomedical Optics Express
Issue number3
StatePublished - Mar 1 2017

ASJC Scopus subject areas

  • Biotechnology
  • Atomic and Molecular Physics, and Optics


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