Refinement and distinction of the chromosome 10p candidate tumor suppressor region in human gliomas

Bertrand C. Liang, Phillip Kish, Donald A. Ross

Research output: Contribution to journalArticlepeer-review

Abstract

Our recent studies have shown that telomeric 10p is frequently deleted in both low and high grade gliomas. Other studies have shown an invariant association of erb-b amplification and loss of chromosome 10. It has not been determined whether this association was specific for a particular locus on chromosome 10. We sought to assess this by examining tumors, for both 10p loss and gene amplification. 55% of tumors showed some degree of allelic imbalance at 10p15. Amplification of erb-b, c-myc, and a mitochondrial cDNA probe, recently found to be amplified in diverse grades of gliomas, was assessed. erb-b and the mitochondrial cDNA probe showed amplification in 28% of the tumors; c-myc gene was amplified in only one astrocytoma. No significant association was noted when comparing the presence of a specific amplified gene, and loss of loci on chromosome. Chromosome 10p15 shows significant loss in glial tumors, and is independent of the chromosome 10 region associated with erb-b amplification. The region at 10p15 is distinct in harboring a putative tumor suppressor gene in gliomas, and is involved earlier in the multi-step pathway to glial tumor malignancy.

Original languageEnglish (US)
Pages (from-to)613-617
Number of pages5
JournalOncology Reports
Volume4
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • astrocytoma
  • c-myc
  • erb-b
  • gene amplification
  • glioblastoma
  • mitochondrial DNA

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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