Refined Analysis of Prostate-specific Antigen Kinetics to Predict Prostate Cancer Active Surveillance Outcomes

Matthew R. Cooperberg, James D. Brooks, Anna V. Faino, Lisa F. Newcomb, James T. Kearns, Peter R. Carroll, Atreya Dash, Ruth Etzioni, Michael D. Fabrizio, Martin E. Gleave, Todd M. Morgan, Peter S. Nelson, Ian M. Thompson, Andrew A. Wagner, Daniel W. Lin, Yingye Zheng

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

In this report, we looked at whether repeat prostate-specific antigen (PSA) measurements, or PSA kinetics, improve prediction of biopsy outcomes in men using active surveillance to manage localized prostate cancer. We found that in a large multicenter active surveillance cohort, PSA kinetics improves the prediction of surveillance biopsy outcome.

Original languageEnglish (US)
Pages (from-to)211-217
Number of pages7
JournalEuropean Urology
Volume74
Issue number2
DOIs
StatePublished - Aug 1 2018
Externally publishedYes

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Keywords

  • Active surveillance
  • Kinetics
  • Outcomes
  • Prostate cancer
  • Prostate-specific antigen

ASJC Scopus subject areas

  • Urology

Cite this

Cooperberg, M. R., Brooks, J. D., Faino, A. V., Newcomb, L. F., Kearns, J. T., Carroll, P. R., Dash, A., Etzioni, R., Fabrizio, M. D., Gleave, M. E., Morgan, T. M., Nelson, P. S., Thompson, I. M., Wagner, A. A., Lin, D. W., & Zheng, Y. (2018). Refined Analysis of Prostate-specific Antigen Kinetics to Predict Prostate Cancer Active Surveillance Outcomes. European Urology, 74(2), 211-217. https://doi.org/10.1016/j.eururo.2018.01.017