Reevaluating goals of insulin therapy: Perspectives from large clinical trials

Matthew C. Riddle, Kevin C.J. Yuen

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Recent large clinical trials have shown that intensive glycemic control can reduce microvascular complications, but appropriate and safe glycemic goals to improve macrovascular outcomes in patients with type 2 diabetes remain poorly defined. This article surveys recent epidemiologic studies and interventional trials, examines the current understanding of the natural history of type 2 diabetes, and proposes new goals and tactics for optimizing insulin therapy.

Original languageEnglish (US)
Pages (from-to)41-56
Number of pages16
JournalEndocrinology and Metabolism Clinics of North America
Volume41
Issue number1
DOIs
StatePublished - Mar 1 2012

Keywords

  • Cardiovascular risk
  • Diabetes
  • Glycemic control
  • Goals
  • Insulin
  • Macrovascular
  • Microvascular
  • Tactics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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