Reductions in parietal and temporal cerebral metabolic rates for glucose are not specific for Alzheimer's disease

Mark B. Schapiro, Pietro Pietrini, Cheryl L. Grady, M. J. Ball, Charles DeCarli, Anand Kumar, Jeffrey A. Kaye, James V. Haxby

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38 Scopus citations


Reduction in the regional cerebral metabolic rate for glucose (rCMRglc) in the parietal and temporal regions has been shown in Alzheimer's disease (AD). The specificity of these findings for this disease state is uncertain. We repeatedly measured rCMRglc with positron emission tomography and [18F]2-fluoro-2-deoxy-D-glucose in the resting state in a 68 year old man with slowly progressive dementia who, during life, was initially diagnosed as having dementia of the Alzheimer type, then Parkinson disease with dementia, but was found to have only Parkinson's disease at necropsy. Metabolic ratios (rCMRglc/mean grey CMRglc) were significantly (p <0 05) reduced in parietal and temporal regions, as well as in the prefrontal and premotor areas. This pattern was similar in regional distribution and magnitude of the defect to that seen in patients with probable AD. These results suggest that reductions of glucose metabolism in association neocortex in AD are not specific to the disease process, but may be related to the dementia state.

Original languageEnglish (US)
Pages (from-to)859-864
Number of pages6
JournalJournal of Neurology, Neurosurgery and Psychiatry
Issue number8
StatePublished - Jan 1 1993


ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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