Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids

William Harris, W. E. Connor, N. Alam, D. R. Illingworth

Research output: Contribution to journalArticle

239 Citations (Scopus)

Abstract

Long chain N-3 fatty acids present in fish oils have been shown to reduce fasting plasma triglyceride and very low density lipoprotein levels in normal and hyperlipidemic human subjects. The present studies were designed to examine whether dietary n-3 fatty acids influence chylomicron formation and metabolism in healthy volunteers. In the first study seven subjects were fed either saturated fat, vegetable oil or fish oil-based diets for 4 weeks each, and test meals containing 50 g of the background fat were administered after the second week of each diet. The postprandial rise in triglyceride levels was significantly lower following the fish oil test meal as compared to the saturated fat or vegetable oil test meals. In the second study, six subjects eating their usual home diets were given two fat tolerance tests. The first contained saturated fat and the second, given 1 week later, contained fish oil. There was no difference in the postprandial triglyceride response between the fish oil and the saturated fat meals. A third study was then conducted with eight volunteers in which saturated fat and fish oil test meals were administered during saturated fat and fish oil background diets in a crossover design. The presence of fish oil in the background diet reduced postprandial lipemia regardless of the type of fat in the test meal. Although there was no effect of the fish oil diet on the lipoprotein lipase and hepatic lipase activity of postheparin plasma measured in vitro, stimulation of in vivo lipolysis was not ruled out. Our results suggest that chronic (but not acute) intake of fish oil may inhibit the synthesis or secretion of chylomicrons from the gut. However, accelerated clearance due to decreased VLDL competition cannot be excluded.

Original languageEnglish (US)
Pages (from-to)1451-1460
Number of pages10
JournalJournal of Lipid Research
Volume29
Issue number11
StatePublished - 1988

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Fish Oils
Omega-3 Fatty Acids
Fats
Nutrition
Meals
Diet
Chylomicrons
Plant Oils
Lipoprotein Lipase
Triglycerides
Plasmas
Lipolysis
Hyperlipidemias
Lipase
Metabolism
Cross-Over Studies
Volunteers
Fasting
Healthy Volunteers
Eating

ASJC Scopus subject areas

  • Endocrinology

Cite this

Harris, W., Connor, W. E., Alam, N., & Illingworth, D. R. (1988). Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research, 29(11), 1451-1460.

Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. / Harris, William; Connor, W. E.; Alam, N.; Illingworth, D. R.

In: Journal of Lipid Research, Vol. 29, No. 11, 1988, p. 1451-1460.

Research output: Contribution to journalArticle

Harris, W, Connor, WE, Alam, N & Illingworth, DR 1988, 'Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids', Journal of Lipid Research, vol. 29, no. 11, pp. 1451-1460.
Harris W, Connor WE, Alam N, Illingworth DR. Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research. 1988;29(11):1451-1460.
Harris, William ; Connor, W. E. ; Alam, N. ; Illingworth, D. R. / Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. In: Journal of Lipid Research. 1988 ; Vol. 29, No. 11. pp. 1451-1460.
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