Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia

B. E. Phillipson, D. W. Rothrock, W. E. Connor, William Harris, D. R. Illingworth

Research output: Contribution to journalArticle

623 Citations (Scopus)

Abstract

Dietary fish oils, which are rich in omega-3 fatty acids, have been reported to reduce plasma lipid levels in normolipidemic subjects. We examined the effects of fish in 20 hypertriglyceridemic patients: 10 with Type IIb hyperlipidemia and 10 with Type V. These patients were put on three diets differing primarily in fatty acid composition and fat content. The control diet contained a fatty acid mixture typical of a low-fat therapeutic diet (ratio of polyunsaturated to saturated fat, 1.4), the fish-oil diet contained omega-3 fatty acids, and the vegetable-oil diet was rich in the omega-6 fatty acid, linoleic acid. Each diet was followed for four weeks. In the Type IIb group, the fish-oil diet led to decreases in both plasma cholesterol (-27 per cent) and triglyceride (-64 per cent), as compared with the control diet. Very-low-density lipoproteins (VLDLs) were also reduced markedly. The vegetable-oil diet had much less effect. With fish oil, the Type V group had marked decreases in total cholesterol and triglyceride levels (-45 and -79 per cent, respectively). VLDL levels were dramatically lowered, as were apoprotein E levels. The vegetable-oil diet (unlike the fish-oil diet) produced a rapid and significant rise in plasma triglyceride levels. We conclude that fish oils and fish may be useful components of diets for the treatment of hypertriglyceridemia.

Original languageEnglish (US)
Pages (from-to)1210-1216
Number of pages7
JournalNew England Journal of Medicine
Volume312
Issue number19
StatePublished - 1985

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Unsaturated Dietary Fats
Apoproteins
Fish Oils
Hypertriglyceridemia
Lipoproteins
Diet
Lipids
Plant Oils
Triglycerides
VLDL Lipoproteins
Omega-3 Fatty Acids
Fishes
Fatty Acids
Omega-6 Fatty Acids
Fats
Cholesterol
Fat-Restricted Diet
Apolipoproteins E
Linoleic Acid
Hyperlipidemias

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Phillipson, B. E., Rothrock, D. W., Connor, W. E., Harris, W., & Illingworth, D. R. (1985). Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. New England Journal of Medicine, 312(19), 1210-1216.

Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. / Phillipson, B. E.; Rothrock, D. W.; Connor, W. E.; Harris, William; Illingworth, D. R.

In: New England Journal of Medicine, Vol. 312, No. 19, 1985, p. 1210-1216.

Research output: Contribution to journalArticle

Phillipson, BE, Rothrock, DW, Connor, WE, Harris, W & Illingworth, DR 1985, 'Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia', New England Journal of Medicine, vol. 312, no. 19, pp. 1210-1216.
Phillipson, B. E. ; Rothrock, D. W. ; Connor, W. E. ; Harris, William ; Illingworth, D. R. / Reduction of plasma lipids, lipoproteins, and apoproteins by dietary fish oils in patients with hypertriglyceridemia. In: New England Journal of Medicine. 1985 ; Vol. 312, No. 19. pp. 1210-1216.
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