Reduction of membrane protein hydrophobicity by site-directed mutagenesis: Introduction of multiple polar residues in helix D of bacteriorhodopsin

Medicine & Life Sciences

• Bacteriorhodopsins 100%
• Hydrophobic and Hydrophilic Interactions 67%
• Site-Directed Mutagenesis 65%
• Halobacterium 54%
• Membrane Proteins 51%
• Lipids 40%
• Retinal Pigments 37%
• Micelles 36%
• Lipid Bilayers 36%
• Amino Acid Substitution 33%
• Glutamine 32%
• Aspartic Acid 32%
• Catalytic Domain 27%
• Proteins 22%
• Light 21%
• Amino Acids 21%

Engineering & Materials Science

• Mutagenesis 97%
• Hydrophobicity 79%
• Proteins 56%
• Membranes 51%
• Lipids 41%
• Pigments 38%
• Amino acids 36%
• Lipid bilayers 24%
• Micelles 23%
• Substitution reactions 15%

Chemical Compounds

• Site-Directed Mutagenesis 63%
• Hydrophobicity 52%
• Reduction 27%
• Protein 25%
• Glutamine Residue 22%
• Retinal 17%
• Aspartate 16%
• Solubilization 14%
• Acid 10%
• Lipid 10%
• Substitution Reaction 9%
• Aqueous Solution 7%
• Surface 4%