Reduction of lymphocele rate in patients undergoing sentinel node biopsy for melanoma by intraoperative placement of plant-based hemostatic powder: Results of a prospective trial

Jennifer Luong, Eric Milanese, Jeanine Fortino, John Vetto

    Research output: Contribution to journalArticle

    Abstract

    Background: Lymphocele is a complication of sentinel node biopsy (SNB) for melanoma. Plant-based hemostatic powder (PBHP) may have a lymphostatic benefit. We studied whether PBHP placed intraoperatively could reduce lymphocele rates. Methods: We performed an open label, prospective, IRB -approved, before- and-after, matched control trial of PBHP placed into the wound in patients undergoing SNB of groin or axillary nodes for melanoma staging. Patient/tumor features and lymphocele rates were compared by standard statistical tests. Results: 66 control and 66 treatment (49 axillary and 17 groin in each arm) SNBs were performed in 61 and 55 patients, respectively, for a total 132 SNBs in 116 patients. Patient and tumor features were similar between groups. Nineteen lymphoceles occurred (14.4%); lymphocele rates were 22.2% (14/66) in the control group and 7.6% (5/66) in the treatment group (p = 0.026). The reduction in lymphocele rates between arms was greater for axillary than for groin sites (87.5% vs. 33%); the axillary reduction was statistically significant (p = 0.030). Conclusions: Intra-operative placement of PBHP reduced the rate of lymphoceles in patients undergoing SNB for melanoma.

    Original languageEnglish (US)
    JournalAmerican journal of surgery
    DOIs
    StatePublished - Jan 1 2019

    Fingerprint

    Lymphocele
    Hemostatics
    Powders
    Melanoma
    Biopsy
    Groin
    Arm
    Research Ethics Committees
    cyhalothrin
    Neoplasms
    Control Groups
    Wounds and Injuries
    Therapeutics

    Keywords

    • Lymphocele
    • Melanoma
    • Plant-based hemostatic powder
    • Prospective trial
    • Reduction

    ASJC Scopus subject areas

    • Surgery

    Cite this

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    title = "Reduction of lymphocele rate in patients undergoing sentinel node biopsy for melanoma by intraoperative placement of plant-based hemostatic powder: Results of a prospective trial",
    abstract = "Background: Lymphocele is a complication of sentinel node biopsy (SNB) for melanoma. Plant-based hemostatic powder (PBHP) may have a lymphostatic benefit. We studied whether PBHP placed intraoperatively could reduce lymphocele rates. Methods: We performed an open label, prospective, IRB -approved, before- and-after, matched control trial of PBHP placed into the wound in patients undergoing SNB of groin or axillary nodes for melanoma staging. Patient/tumor features and lymphocele rates were compared by standard statistical tests. Results: 66 control and 66 treatment (49 axillary and 17 groin in each arm) SNBs were performed in 61 and 55 patients, respectively, for a total 132 SNBs in 116 patients. Patient and tumor features were similar between groups. Nineteen lymphoceles occurred (14.4{\%}); lymphocele rates were 22.2{\%} (14/66) in the control group and 7.6{\%} (5/66) in the treatment group (p = 0.026). The reduction in lymphocele rates between arms was greater for axillary than for groin sites (87.5{\%} vs. 33{\%}); the axillary reduction was statistically significant (p = 0.030). Conclusions: Intra-operative placement of PBHP reduced the rate of lymphoceles in patients undergoing SNB for melanoma.",
    keywords = "Lymphocele, Melanoma, Plant-based hemostatic powder, Prospective trial, Reduction",
    author = "Jennifer Luong and Eric Milanese and Jeanine Fortino and John Vetto",
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    T1 - Reduction of lymphocele rate in patients undergoing sentinel node biopsy for melanoma by intraoperative placement of plant-based hemostatic powder

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    AU - Luong, Jennifer

    AU - Milanese, Eric

    AU - Fortino, Jeanine

    AU - Vetto, John

    PY - 2019/1/1

    Y1 - 2019/1/1

    N2 - Background: Lymphocele is a complication of sentinel node biopsy (SNB) for melanoma. Plant-based hemostatic powder (PBHP) may have a lymphostatic benefit. We studied whether PBHP placed intraoperatively could reduce lymphocele rates. Methods: We performed an open label, prospective, IRB -approved, before- and-after, matched control trial of PBHP placed into the wound in patients undergoing SNB of groin or axillary nodes for melanoma staging. Patient/tumor features and lymphocele rates were compared by standard statistical tests. Results: 66 control and 66 treatment (49 axillary and 17 groin in each arm) SNBs were performed in 61 and 55 patients, respectively, for a total 132 SNBs in 116 patients. Patient and tumor features were similar between groups. Nineteen lymphoceles occurred (14.4%); lymphocele rates were 22.2% (14/66) in the control group and 7.6% (5/66) in the treatment group (p = 0.026). The reduction in lymphocele rates between arms was greater for axillary than for groin sites (87.5% vs. 33%); the axillary reduction was statistically significant (p = 0.030). Conclusions: Intra-operative placement of PBHP reduced the rate of lymphoceles in patients undergoing SNB for melanoma.

    AB - Background: Lymphocele is a complication of sentinel node biopsy (SNB) for melanoma. Plant-based hemostatic powder (PBHP) may have a lymphostatic benefit. We studied whether PBHP placed intraoperatively could reduce lymphocele rates. Methods: We performed an open label, prospective, IRB -approved, before- and-after, matched control trial of PBHP placed into the wound in patients undergoing SNB of groin or axillary nodes for melanoma staging. Patient/tumor features and lymphocele rates were compared by standard statistical tests. Results: 66 control and 66 treatment (49 axillary and 17 groin in each arm) SNBs were performed in 61 and 55 patients, respectively, for a total 132 SNBs in 116 patients. Patient and tumor features were similar between groups. Nineteen lymphoceles occurred (14.4%); lymphocele rates were 22.2% (14/66) in the control group and 7.6% (5/66) in the treatment group (p = 0.026). The reduction in lymphocele rates between arms was greater for axillary than for groin sites (87.5% vs. 33%); the axillary reduction was statistically significant (p = 0.030). Conclusions: Intra-operative placement of PBHP reduced the rate of lymphoceles in patients undergoing SNB for melanoma.

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    KW - Melanoma

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