Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

Wayne Clark, K. P. Madden, R. Rothlein, J. A. Zivin

Research output: Contribution to journalArticle

170 Citations (Scopus)

Abstract

Activated leukocytes appear to be directly involved in potentiating ischemic central nervous system (CNS) injury. Adhesion of leukocytes to endothelium is essential for their migration and requires the binding of adhesion receptors of the leukocyte (CD 18) to an intercellular adhesion molecule (ICAM) on endothelium. Monoclonal antibodies to an ICAM can block leukocyte adhesion and transendothelial migration. To determine the efficacy of anti-ICAM antibody treatment in preserving neurological function after CNS ischemia, two animal models were used. A 1-mg/kg dose of anti-ICAM was given to rabbits 30 minutes before induction of ischemia either in the spinal cord using temporary aortic occlusion or in the brain using intra-arterial microspheres. In this study, treatment with anti-ICAM produced a significant reduction in neurological deficits in the reversible spinal cord ischemia model but not in the irreversible brain ischemia model. This protective effect supports the active role of leukocytes in CNS reperfusion ischemic injury and offers potential for future therapy.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalJournal of Neurosurgery
Volume75
Issue number4
StatePublished - 1991

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Nervous System Trauma
Cell Adhesion Molecules
Central Nervous System
Monoclonal Antibodies
Leukocytes
Endothelium
Leukocyte-Adhesion Receptors
Ischemia
Spinal Cord Ischemia
Transendothelial and Transepithelial Migration
Reperfusion Injury
Brain Ischemia
Microspheres
Spinal Cord
Animal Models
Rabbits
Antibodies
Brain

Keywords

  • cell adhesion
  • ischemia
  • leukocyte
  • monoclonal antibody
  • rabbit
  • reperfusion injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule. / Clark, Wayne; Madden, K. P.; Rothlein, R.; Zivin, J. A.

In: Journal of Neurosurgery, Vol. 75, No. 4, 1991, p. 623-627.

Research output: Contribution to journalArticle

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