Reduction of Amphotericin B Nephrotoxicity With Mannitol

Josef Rosch, George J. Pazin, Philip Fireman

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Amphotericin B in combination with mannitol was given to a patient who had mucocutaneous candidiasis and moderate renal insufficiency. Previously, amphotericin B alone had induced an abrupt increase in serum creatinine and urea nitrogen, but when mannitol was given concurrently there was no worsening of renal function. Thus, amphotericin B with mannitol appears to offer a less nephrotoxic but equally candicidal therapeutic regimen in the renal compromised patient requiring parenteral candicidal therapy.

Original languageEnglish (US)
Pages (from-to)1995-1996
Number of pages2
JournalJAMA - Journal of the American Medical Association
Volume235
Issue number18
DOIs
StatePublished - May 3 1976
Externally publishedYes

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Amphotericin B
Mannitol
Kidney
Candidiasis
Renal Insufficiency
Urea
Creatinine
Nitrogen
Therapeutics
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Reduction of Amphotericin B Nephrotoxicity With Mannitol. / Rosch, Josef; Pazin, George J.; Fireman, Philip.

In: JAMA - Journal of the American Medical Association, Vol. 235, No. 18, 03.05.1976, p. 1995-1996.

Research output: Contribution to journalArticle

Rosch, Josef ; Pazin, George J. ; Fireman, Philip. / Reduction of Amphotericin B Nephrotoxicity With Mannitol. In: JAMA - Journal of the American Medical Association. 1976 ; Vol. 235, No. 18. pp. 1995-1996.
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