Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics

Harold L. Manning, Steven Shea, Richard M. Schwartzstein, Robert W. Lansing, Robert Brown, Robert B. Banzett

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

The act of breathing diminishes the discomfort associated with hypercapnia and breath-holding. To investigate the mechanisms involved in this effect, we studied the effect of tidal volume (VT) on CO2-evoked air hunger in 5 high-level quadriplegic subjects whose ventilatory capacity was negligible, and who lacked sensory information from the chest wall. Subjects were ventilated at constant frequency with a hyperoxic gas mixture, and end-tidal PCO2 was maintained at a constant but elevated level. VT was varied between the subjects' normal VT and a smaller VT. Subjects used a category scale to rate their respiratory discomfort or 'air hunger' at 30-40 sec intervals. In 4 of 5 subjects there was a strong inverse relationship between breath size and air hunger ratings. The quality of the sensation associated with reduced VT was nearly identical to that previously experienced with CO2 alone. We conclude that afferent information from the lungs and upper airways is sufficient to modify the sensation of air hunger.

Original languageEnglish (US)
Pages (from-to)19-30
Number of pages12
JournalRespiration Physiology
Volume90
Issue number1
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

Hunger
Tidal Volume
Air
Breath Holding
Hypercapnia
Thoracic Wall
Respiratory Rate
Respiration
Gases
Lung

Keywords

  • Breathlessness CO
  • CO
  • Control of breathing
  • Dyspnea
  • humans
  • Mammals
  • respiratory sensation
  • tidal volume (quadriplegics)

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Manning, H. L., Shea, S., Schwartzstein, R. M., Lansing, R. W., Brown, R., & Banzett, R. B. (1992). Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics. Respiration Physiology, 90(1), 19-30. https://doi.org/10.1016/0034-5687(92)90131-F

Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics. / Manning, Harold L.; Shea, Steven; Schwartzstein, Richard M.; Lansing, Robert W.; Brown, Robert; Banzett, Robert B.

In: Respiration Physiology, Vol. 90, No. 1, 1992, p. 19-30.

Research output: Contribution to journalArticle

Manning, HL, Shea, S, Schwartzstein, RM, Lansing, RW, Brown, R & Banzett, RB 1992, 'Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics', Respiration Physiology, vol. 90, no. 1, pp. 19-30. https://doi.org/10.1016/0034-5687(92)90131-F
Manning, Harold L. ; Shea, Steven ; Schwartzstein, Richard M. ; Lansing, Robert W. ; Brown, Robert ; Banzett, Robert B. / Reduced tidal volume increases 'air hunger' at fixed PCO2 in ventilated quadriplegics. In: Respiration Physiology. 1992 ; Vol. 90, No. 1. pp. 19-30.
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