Reduced systolic pressure load decreases cell-cycle activity in the fetal sheep heart

P. F. O'Tierney, Debra Anderson, J. J. Faber, Samantha Louey, Kent Thornburg, George Giraud

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    19 Citations (Scopus)

    Abstract

    The fetal heart is highly sensitive to changes in mechanical load. We have previously demonstrated that increased cardiac load can stimulate cell cycle activity and maturation of immature cardiomyocytes, but the effects of reduced load are not known. Sixteen fetal sheep were given either continuous intravenous infusion of lactated Ringer solution (LR) or enalaprilat, an angiotensin-converting enzyme inhibitor beginning at 127 days gestational age. After 8 days, fetal arterial pressure in the enalaprilat-infused fetuses (23.8 ± 2.8 mmHg) was lower than that of control fetuses (47.5 ± 4.7 mmHg) (P <0.0001). Although the body weights of the two groups of fetuses were similar, the heart weight-to-body weight ratios of the enalaprilat-infused fetuses were less than those of the LR-infused fetuses (5.6 ± 0.5 g/kg vs. 7.0 ± 0.6 g/kg, P <0.0001). Dimensions of ventricular myocytes were not different between control and enalaprilat-infused fetuses. However, there was a significant decrease in cell cycle activity in both the right ventricle (P <0.005) and the left ventricle (P <0.002) of the enalaprilat-infused fetuses. Thus, we conclude a sustained reduction in systolic pressure load decreases hyperplastic growth in the fetal heart.

    Original languageEnglish (US)
    JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
    Volume299
    Issue number2
    DOIs
    StatePublished - Aug 2010

    Fingerprint

    Fetal Heart
    Enalaprilat
    Sheep
    Cell Cycle
    Fetus
    Blood Pressure
    Heart Ventricles
    Body Weight
    Angiotensin-Converting Enzyme Inhibitors
    Cardiac Myocytes
    Intravenous Infusions
    Muscle Cells
    Gestational Age
    Arterial Pressure
    Weights and Measures
    Growth

    Keywords

    • Blood pressure
    • Cardiomyocyte
    • Enalaprilat
    • Hyperplasia

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)

    Cite this

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    AU - Anderson, Debra

    AU - Faber, J. J.

    AU - Louey, Samantha

    AU - Thornburg, Kent

    AU - Giraud, George

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