Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat

R. A. Steiner, W. J. Bremner, D. K. Clifton, Daniel Dorsa

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

To identify possible age-dependent changes in the feedback relationship between the brain-pituitary and testes, we examined the minute-to-minute patterns of plasma luteinizing hormone (LH) and testosterone (T) in intact, young male rats and compared these profiles to those of old animals. Young (3 mo; n=11) and old (22 mo; n=12) Spraque-Dawley rats were fitted with indwelling venous catheters and between 24 and 48 hr later, were bled without anesthesia, by remote sampling, at 10-min intervals for 8 h. Blood samples of 400 μl were withdrawn, and an equivalent volume of a blood replacement mixture was infused after each sample. Plasma LH and T levels in each sample were measured by radioimmunoassay (RIA). Plasma T levels in old animals failed to show the transient oscillations observed in young animals. Mean plasma T levels were 50% lower in old compared to young animals (P

Original languageEnglish (US)
Pages (from-to)251-258
Number of pages8
JournalBiology of Reproduction
Volume31
Issue number2
StatePublished - 1984
Externally publishedYes

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Luteinizing Hormone
Testosterone
Indwelling Catheters
Blood Volume
Radioimmunoassay
Testis
Anesthesia
Brain

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Embryology

Cite this

Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat. / Steiner, R. A.; Bremner, W. J.; Clifton, D. K.; Dorsa, Daniel.

In: Biology of Reproduction, Vol. 31, No. 2, 1984, p. 251-258.

Research output: Contribution to journalArticle

Steiner, R. A. ; Bremner, W. J. ; Clifton, D. K. ; Dorsa, Daniel. / Reduced pulsatile luteinizing hormone and testosterone secretion with aging in the male rat. In: Biology of Reproduction. 1984 ; Vol. 31, No. 2. pp. 251-258.
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