Abstract
Haploidentical SCT (HaploSCT) has been most commonly performed using a myeloablative, TBI-based preparative regimen; however, the toxicity with this approach remains very high. We studied the feasibility of a reduced-intensity conditioning regimen in a phase II clinical trial using fludarabine, melphalan and thiotepa and antithymocyte globulin (ATG) for patients with advanced hematological malignancies undergoing T-cell depleted HaploSCT. Twenty-eight patients were entered in the study. Engraftment with donor-derived hematopoiesis was achieved in 78 of patients after a median of 13 days. Six patients experienced primary graft failure, three out of four tested patients had donor-specific anti-HLA antibodies (DSA) (P0.001). Toxicity included mostly infections. A total of 21 out of 22 patients with AMLmyelodysplastic syndrome (MDS) achieved remission after transplant (16 with relapsedrefractory AML). Five out of the 12 patients (42) with AMLMDS with <15 BM blasts survived long term as compared with none with more advanced disease (P0.03). HaploSCT with this fludarabine, melphalan and thiotepa and ATG RIC is an effective, well-tolerated conditioning regimen for patients with AMLMDS with low disease burden at the time of transplant and allowed a high rate of engraftment in patients without DSA. Patients with overt relapse fared poorly and require novel treatment strategies.
Original language | English (US) |
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Pages (from-to) | 429-436 |
Number of pages | 8 |
Journal | Bone marrow transplantation |
Volume | 45 |
Issue number | 3 |
DOIs | |
State | Published - 2010 |
Externally published | Yes |
Keywords
- AML
- Haploidentical SCT
- Myelodysplastic syndromes
- T-cell depletion
ASJC Scopus subject areas
- Hematology
- Transplantation