Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats

L. J. Stein, Daniel Dorsa, D. G. Baskin, D. P. Figlewicz, D. Porte, S. C. Woods

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Abstract

To test the effect of chronic hyperinsulinemia on cerebrospinal fluid (CSF) insulin concentrations in the obese (fafa) Zucker rat, obese and heterozygote lean (Fafa) rats were infused peripherally with insulin or vehicle for 6 days. Both basal levels and the increase of plasma immunoreactive insulin (IRI) were greater in fafa (increase = 713 μU/ml) than in Fafa (increase = 392 μU/ml) rats, P <0.0001. Vehicle-infused fafa rats had higher CSF IRI levels than did vehicle-infused Fafa rats (4.3 ± 1.2 μU/ml vs. 1.5 ± 0.4 μU/ml, P <0.01). CSF IRI was elevated in both insulin-infused groups (P <0.001). After insulin infusion Fafa rats had higher CSF IRI levels than did fafa rats (Fafa: 10.0 ± 1.8 μU/ml vs. fafa: 7.1 ± 0.1 μU/ml). In contrast to the effect of insulin infusion on plasma IRI, the increase of CSF IRI was greater in Fafa rats (8.5 μU/ml) than in fafa rats (4.0 μU/ml, P <0.001). Uptake of insulin from the periphery to the CSF therefore appears to be reduced in obese fafa Zucker rats compared to lean Fafa controls.

Original languageEnglish (US)
Pages (from-to)1611-1615
Number of pages5
JournalEndocrinology
Volume121
Issue number5
StatePublished - 1987
Externally publishedYes

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Zucker Rats
Hyperinsulinism
Cerebrospinal Fluid
Insulin
Heterozygote

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats. / Stein, L. J.; Dorsa, Daniel; Baskin, D. G.; Figlewicz, D. P.; Porte, D.; Woods, S. C.

In: Endocrinology, Vol. 121, No. 5, 1987, p. 1611-1615.

Research output: Contribution to journalArticle

Stein, L. J. ; Dorsa, Daniel ; Baskin, D. G. ; Figlewicz, D. P. ; Porte, D. ; Woods, S. C. / Reduced effect of experimental peripheral hyperinsulinemia to elevate cerebrospinal fluid insulin concentrations of obese Zucker rats. In: Endocrinology. 1987 ; Vol. 121, No. 5. pp. 1611-1615.
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AU - Woods, S. C.

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