Redox signaling at invasive microdomains in cancer cells

Begoña Díaz, Sara Courtneidge

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Redox signaling contributes to the regulation of cancer cell proliferation, survival, and invasion and participates in the adaptation of cancer cells to their microenvironment. NADPH oxidases are important mediators of redox signaling in normal and cancer cells. Redox signal specificity in normal cells is in part achieved by targeting enzymes that generate reactive oxygen species to specific subcellular microdomains such as focal adhesions, dorsal ruffles, lipid rafts, or caveolae. In a similar fashion, redox signal specificity during cancer cell invasion can be regulated by targeting reactive oxygen generation to invasive microdomains such as invadopodia. Here we summarize recent advances in the understanding of the redox signaling processes that control the cancer cell proinvasive program by modulating cell adhesion, migration, and proteolysis as well as the interaction of cancer cells with the tumor microenvironment. We focus on redox signaling events mediated by invadopodia NADPH oxidase complexes and their contribution to cancer cell invasion.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalFree Radical Biology and Medicine
Volume52
Issue number2
DOIs
StatePublished - Jan 15 2012
Externally publishedYes

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Oxidation-Reduction
Cells
Neoplasms
NADPH Oxidase
Proteolysis
Cell adhesion
Caveolae
Cell proliferation
Focal Adhesions
Tumor Microenvironment
Process control
Tumors
Reactive Oxygen Species
Cell Adhesion
Cell Communication
Adhesion
Cell Movement
Cell Survival
Oxygen
Lipids

Keywords

  • Cancer
  • Free radicals
  • Invadopodia
  • Invasion
  • Migration
  • NADPH oxidase
  • Nox1
  • Nox4
  • p22phox
  • PTPs
  • Redox
  • ROS
  • Signaling
  • Tks4
  • Tks5

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

Cite this

Redox signaling at invasive microdomains in cancer cells. / Díaz, Begoña; Courtneidge, Sara.

In: Free Radical Biology and Medicine, Vol. 52, No. 2, 15.01.2012, p. 247-256.

Research output: Contribution to journalArticle

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