Recurrent sites for new centromere seeding

Mario Ventura, Stefania Weigl, Lucia Carbone, Maria Francesca Cardone, Doriana Misceo, Mariagrazia Teti, Peitro D'Addabbo, Annelise Wandall, Erik Björck, Pieter J. de Jong, Xinwei She, Evan E. Eichler, Nicoletta Archidiacono, Mariano Rocchi

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Using comparative FISH and genomics, we have studied and compared the evolution of chromosome 3 in primates and two human neocentromere cases on the long arm of this chromosome. Our results show that one of the human neocentromere cases maps to the same 3q26 chromosomal region where a new centromere emerged in a common ancestor of the Old World monkeys ∼25-40 million years ago. Similarly, the locus in which a new centromere was seeded in the great apes' ancestor was orthologous to the site in which a new centromere emerged in the New World monkeys' ancestor. These data suggest the recurrent use of longstanding latent centromeres and that there is an inherent potential of these regions to form centromeres. The second human neocentromere case (3q24) revealed unprecedented features. The neocentromere emergence was not accompanied by any chromosomal rearrangement that usually triggers these events. Instead, it involved the functional inactivation of the normal centromere, and was present in an otherwise phenotypically normal individual who transmitted this unusual chromosome to the next generation. We propose that the formation of neocentromeres in humans and the emergence of new centromeres during the course of evolution share a common mechanism.

Original languageEnglish (US)
Pages (from-to)1696-1703
Number of pages8
JournalGenome Research
Volume14
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

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Centromere
Chromosomes
Platyrrhini
Cercopithecidae
Chromosomes, Human, Pair 3
Hominidae
Genomics
Primates

ASJC Scopus subject areas

  • Genetics

Cite this

Ventura, M., Weigl, S., Carbone, L., Cardone, M. F., Misceo, D., Teti, M., ... Rocchi, M. (2004). Recurrent sites for new centromere seeding. Genome Research, 14(9), 1696-1703. https://doi.org/10.1101/gr.2608804

Recurrent sites for new centromere seeding. / Ventura, Mario; Weigl, Stefania; Carbone, Lucia; Cardone, Maria Francesca; Misceo, Doriana; Teti, Mariagrazia; D'Addabbo, Peitro; Wandall, Annelise; Björck, Erik; de Jong, Pieter J.; She, Xinwei; Eichler, Evan E.; Archidiacono, Nicoletta; Rocchi, Mariano.

In: Genome Research, Vol. 14, No. 9, 09.2004, p. 1696-1703.

Research output: Contribution to journalArticle

Ventura, M, Weigl, S, Carbone, L, Cardone, MF, Misceo, D, Teti, M, D'Addabbo, P, Wandall, A, Björck, E, de Jong, PJ, She, X, Eichler, EE, Archidiacono, N & Rocchi, M 2004, 'Recurrent sites for new centromere seeding', Genome Research, vol. 14, no. 9, pp. 1696-1703. https://doi.org/10.1101/gr.2608804
Ventura M, Weigl S, Carbone L, Cardone MF, Misceo D, Teti M et al. Recurrent sites for new centromere seeding. Genome Research. 2004 Sep;14(9):1696-1703. https://doi.org/10.1101/gr.2608804
Ventura, Mario ; Weigl, Stefania ; Carbone, Lucia ; Cardone, Maria Francesca ; Misceo, Doriana ; Teti, Mariagrazia ; D'Addabbo, Peitro ; Wandall, Annelise ; Björck, Erik ; de Jong, Pieter J. ; She, Xinwei ; Eichler, Evan E. ; Archidiacono, Nicoletta ; Rocchi, Mariano. / Recurrent sites for new centromere seeding. In: Genome Research. 2004 ; Vol. 14, No. 9. pp. 1696-1703.
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