Rectal diazepam gel for treatment of acute repetitive seizures

Robert L. Kriel, James C. Cloyd, John M. Pellock, Wendy G. Mitchell, James J. Cereghino, N. Paul Rosman

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

The purpose of these investigations was to determine from combined data the response to rectal diazepam (DZP) gel (Diastat [Athena Neurosciences, South San Francisco, CA]) in home treatment of children with episodes of acute repetitive seizures (ARS). A subset of patients aged 2-17 years were selected from two prospective placebo-controlled studies of children and adults. In both studies a prospective, double-blind, placebo-controlled design was used. The treatment groups (68 DZP; 65 placebo) did not differ significantly in age, race, seizure type or etiology, or in the median number of ARS episodes per month before study entry. DZP-treated children demonstrated a significant reduction in median seizure frequency compared with the placebo group (0.00 vs 0.25 seizures per hour, P = 0.001). Significantly more DZP-treated children remained seizure free during the observation period (40 vs 20, P = 0.001). Somnolence was the only adverse effect present significantly more often in the DZP-treated children (25.0% vs 7.7%, P = 0.0095). There were no instances of serious respiratory depression. Rectal DZP was demonstrated to be an effective and safe treatment to abort an episode of ARS in a child and, additionally, lessened the likelihood of seizure recurrence within the next 12 hours.

Original languageEnglish (US)
Pages (from-to)282-288
Number of pages7
JournalPediatric Neurology
Volume20
Issue number4
DOIs
StatePublished - Apr 1 1999

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Kriel, R. L., Cloyd, J. C., Pellock, J. M., Mitchell, W. G., Cereghino, J. J., & Rosman, N. P. (1999). Rectal diazepam gel for treatment of acute repetitive seizures. Pediatric Neurology, 20(4), 282-288. https://doi.org/10.1016/S0887-8994(98)00156-8